Usefulness of serum opsonic activity measured by chemiluminescence method to assess the invasiveness of colorectal endoscopic mucosal dissection

Endoscopic sub-mucosal dissection (ESD) is considered as a low-invasive treatment for early-stage colorectal cancer, but the degree of invasiveness has not been well investigated. The aim of this study was to evaluate the physical stress due to colorectal ESD based on changes in serum opsonic activi...

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Published in:Free radical research 2020-12, Vol.54 (11-12), p.810-817
Main Authors: Chinda, Daisuke, Shimoyama, Tadashi, Arai, Tetsu, Sawada, Kaori, Akitaya, Kazuki, Kudo, Sae, Yasuda, Kohei, Miyazawa, Kuniaki, Akimoto, Naoki, Sato, Satoshi, Hayamizu, Shiro, Tatsuta, Tetsuya, Kikuchi, Hidezumi, Hiraga, Hiroto, Sawaya, Manabu, Sakuraba, Hirotake, Mikami, Tatsuya, Nakaji, Shigeyuki, Fukuda, Shinsaku
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Chemiluminescence method
colorectal endoscopic sub-mucosal dissection
Colorectal Neoplasms - diagnosis
Colorectal Neoplasms - surgery
Dissection
early colorectal cancer
Endoscopy - methods
Exophthalmos
Female
Humans
Luminescence
Male
Middle Aged
Neoplasm Invasiveness
Receptors, Immunologic - metabolism
serum opsonic activity
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Summary:Endoscopic sub-mucosal dissection (ESD) is considered as a low-invasive treatment for early-stage colorectal cancer, but the degree of invasiveness has not been well investigated. The aim of this study was to evaluate the physical stress due to colorectal ESD based on changes in serum opsonic activity (SOA). SOA was examined by measuring reactive oxygen species (ROS) produced by neutrophils using lucigenin-dependent chemiluminescence (LgCL) and luminol-dependent chemiluminescence (LmCL). Sixty-nine patients were enrolled into the study and examined SOA in the morning of the day of ESD, the next day, and at four days after ESD. The peak height (PH) and area under the curve (AUC) of LgCL showed no significant difference between the day and the next day, whereas the PH and AUC for LgCL were significantly higher four days after ESD than on the day of ESD (p 
ISSN:1071-5762
1029-2470
DOI:10.1080/10715762.2019.1681590