Extracellular vesicles released by ovarian carcinoma contain arginase 1 that mitigates antitumor immune response

Expression of arginase-1 (ARG1) is an immunosuppressive feature of tumor microenvironment that leads to depletion of ʟ-arginine, a nutrient required for T-cells expansion. Ovarian carcinoma cells release extracellular vesicles carrying enzymatically active ARG1, that contributes to local and systemi...

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Bibliographic Details
Published in:Oncoimmunology 2019-11, Vol.8 (11), p.e1655370-e1655370
Main Authors: Sosnowska, Anna, Czystowska-Kuzmicz, Malgorzata, Golab, Jakub
Format: Article
Language:English
Subjects:
Arginase
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extracellular vesicles
immunotherapy
ovarian carcinoma
T-cells response
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Summary:Expression of arginase-1 (ARG1) is an immunosuppressive feature of tumor microenvironment that leads to depletion of ʟ-arginine, a nutrient required for T-cells expansion. Ovarian carcinoma cells release extracellular vesicles carrying enzymatically active ARG1, that contributes to local and systemic immune suppression, which can be restored by ARG inhibitor.
ISSN:2162-4011
2162-402X
2162-402X
DOI:10.1080/2162402X.2019.1655370