Critical and diverse roles of phosphates in human bone formation

Humans utilise biomineralisation in the formation of bone and teeth. Human biomineralisation processes are defined by the transformation of an amorphous phosphate-based precursor to highly organised nanocrystals. Interestingly, ionic phosphate species not only provide a fundamental building block of...

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Bibliographic Details
Published in:Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2019-12, Vol.7 (47), p.746-747
Main Authors: Hughes, Erik A. B, Robinson, Thomas E, Bassett, David B, Cox, Sophie C, Grover, Liam M
Format: Article
Language:English
Subjects:
Bone growth
Crystallization
Nanocrystals
Nucleation
Osteogenesis
Phosphates
Teeth
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Summary:Humans utilise biomineralisation in the formation of bone and teeth. Human biomineralisation processes are defined by the transformation of an amorphous phosphate-based precursor to highly organised nanocrystals. Interestingly, ionic phosphate species not only provide a fundamental building block of biological mineral, but rather exhibit several diverse roles in mediating mineral formation in the physiological milieu. In this review, we focus on elucidating the complex roles of phosphate ions and molecules within human biomineralisation pathways, primarily referring to the nucleation and crystallisation of bone mineral. The interconnecting roles of phosphates in bone mineral formation.
ISSN:2050-750X
2050-7518
DOI:10.1039/c9tb02011j