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Early anemia and neonatal morbidity in extremely low birth-weight preterm infants
Extremely low birth-weight (ELBW) preterm infants remain at high risk for mortality and major morbidities, and nearly all need packed red blood cell transfusions within their first weeks of life. The overall objective of this study was to assess the association between anemia at admission to neonata...
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| Published in: | The journal of maternal-fetal & neonatal medicine 2021-11, Vol.34 (22), p.3697-3703 |
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| container_title | The journal of maternal-fetal & neonatal medicine |
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| creator | Rocha, Gustavo Pereira, Sandra Antunes-Sarmento, João Flôr-de-Lima, Filipa Soares, Henrique Guimarães, Hercília |
| description | Extremely low birth-weight (ELBW) preterm infants remain at high risk for mortality and major morbidities, and nearly all need packed red blood cell transfusions within their first weeks of life. The overall objective of this study was to assess the association between anemia at admission to neonatal intensive care unit (NICU) with the neonatal morbidity and mortality in ELBW infants.
This retrospective study was conducted on 106 patients with ELBW admitted at our level III NICU from January 2006 to December 2015. The subjects were divided into two groups: (1) patients with anemia at admission and (2) patients without anemia. Their characteristics and outcomes were compared. Statistical analysis was performed using the Statistical Package for the Social Sciences software, version 24.0 (IBM New York, USA), and a value of p |
| doi_str_mv | 10.1080/14767058.2019.1689948 |
| format | article |
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This retrospective study was conducted on 106 patients with ELBW admitted at our level III NICU from January 2006 to December 2015. The subjects were divided into two groups: (1) patients with anemia at admission and (2) patients without anemia. Their characteristics and outcomes were compared. Statistical analysis was performed using the Statistical Package for the Social Sciences software, version 24.0 (IBM New York, USA), and a value of p < 0.05 was considered statistically significant.
Of the 106 ELBW, 34 (32%) presented with anemia at admission and 72 (68%) without anemia. Anemia-naive presented mean hemoglobin at the admission of 12.8 ± 1.5 g/dl and nonanemic 16.8 ± 2.1 g/dl, p < .001). The anemic group presented a lower gestational age (26 ± 2 vs. 27 ± 2 SD weeks, p = .025), greater need for inotropic support (52.9 vs. 31.9%, p = .041), longer period of invasive mechanical ventilation (9 vs. 2 days, p = .012), higher FiO
2
need (0.8 vs. 0.4, p < .001), more frequent hemodynamically significant patent ductus arteriosus (HS-PDA) (64.7 vs. 41.7%, p = .006) and severe intra-periventricular hemorrhage (IPVH) (41.2 vs. 16.7%, p = 0.005). The multivariate analysis confirmed an association between anemia at admission and HS-PDA (OR = 3.2; 95% CI: 1.1-9.5, p = 0.044) and severe IPVH (OR = 3.3; 95% CI: 1.0-9.9, p = .038). In anemic infants, ionotropic support and IPVH >2 were considered independent factors for mortality.
In this ELBW series, the presence of anemia at admission to the NICU was associated with HS-PDA and severe IPVH. Preventive strategies for early anemia must be encouraged.</description><identifier>ISSN: 1476-7058</identifier><identifier>EISSN: 1476-4954</identifier><identifier>DOI: 10.1080/14767058.2019.1689948</identifier><identifier>PMID: 31736385</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>Anemia ; Anemia - epidemiology ; Ductus Arteriosus, Patent ; extremely low birth-weight infant ; Humans ; Infant, Extremely Low Birth Weight ; Infant, Newborn ; Infant, Premature ; intraventricular hemorrhage ; Morbidity ; newborn ; packed red blood cells transfusion ; patent ductus arteriosus ; Retrospective Studies</subject><ispartof>The journal of maternal-fetal & neonatal medicine, 2021-11, Vol.34 (22), p.3697-3703</ispartof><rights>2019 Informa UK Limited, trading as Taylor & Francis Group 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c366t-3dfbd3080ec106e50ed60b0b0b5435c8e6b6260d97acc8d44eb08cc97f01cc6d3</citedby><cites>FETCH-LOGICAL-c366t-3dfbd3080ec106e50ed60b0b0b5435c8e6b6260d97acc8d44eb08cc97f01cc6d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31736385$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rocha, Gustavo</creatorcontrib><creatorcontrib>Pereira, Sandra</creatorcontrib><creatorcontrib>Antunes-Sarmento, João</creatorcontrib><creatorcontrib>Flôr-de-Lima, Filipa</creatorcontrib><creatorcontrib>Soares, Henrique</creatorcontrib><creatorcontrib>Guimarães, Hercília</creatorcontrib><title>Early anemia and neonatal morbidity in extremely low birth-weight preterm infants</title><title>The journal of maternal-fetal & neonatal medicine</title><addtitle>J Matern Fetal Neonatal Med</addtitle><description>Extremely low birth-weight (ELBW) preterm infants remain at high risk for mortality and major morbidities, and nearly all need packed red blood cell transfusions within their first weeks of life. The overall objective of this study was to assess the association between anemia at admission to neonatal intensive care unit (NICU) with the neonatal morbidity and mortality in ELBW infants.
This retrospective study was conducted on 106 patients with ELBW admitted at our level III NICU from January 2006 to December 2015. The subjects were divided into two groups: (1) patients with anemia at admission and (2) patients without anemia. Their characteristics and outcomes were compared. Statistical analysis was performed using the Statistical Package for the Social Sciences software, version 24.0 (IBM New York, USA), and a value of p < 0.05 was considered statistically significant.
Of the 106 ELBW, 34 (32%) presented with anemia at admission and 72 (68%) without anemia. Anemia-naive presented mean hemoglobin at the admission of 12.8 ± 1.5 g/dl and nonanemic 16.8 ± 2.1 g/dl, p < .001). The anemic group presented a lower gestational age (26 ± 2 vs. 27 ± 2 SD weeks, p = .025), greater need for inotropic support (52.9 vs. 31.9%, p = .041), longer period of invasive mechanical ventilation (9 vs. 2 days, p = .012), higher FiO
2
need (0.8 vs. 0.4, p < .001), more frequent hemodynamically significant patent ductus arteriosus (HS-PDA) (64.7 vs. 41.7%, p = .006) and severe intra-periventricular hemorrhage (IPVH) (41.2 vs. 16.7%, p = 0.005). The multivariate analysis confirmed an association between anemia at admission and HS-PDA (OR = 3.2; 95% CI: 1.1-9.5, p = 0.044) and severe IPVH (OR = 3.3; 95% CI: 1.0-9.9, p = .038). In anemic infants, ionotropic support and IPVH >2 were considered independent factors for mortality.
In this ELBW series, the presence of anemia at admission to the NICU was associated with HS-PDA and severe IPVH. Preventive strategies for early anemia must be encouraged.</description><subject>Anemia</subject><subject>Anemia - epidemiology</subject><subject>Ductus Arteriosus, Patent</subject><subject>extremely low birth-weight infant</subject><subject>Humans</subject><subject>Infant, Extremely Low Birth Weight</subject><subject>Infant, Newborn</subject><subject>Infant, Premature</subject><subject>intraventricular hemorrhage</subject><subject>Morbidity</subject><subject>newborn</subject><subject>packed red blood cells transfusion</subject><subject>patent ductus arteriosus</subject><subject>Retrospective Studies</subject><issn>1476-7058</issn><issn>1476-4954</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kE1LAzEQhoMotlZ_grJHL1uTZpPN3pRSP6Aggp5DNpm1kd1NTVJq_71Z2nqUHCYMz8zwPghdEzwlWOA7UpS8xExMZ5hUU8JFVRXiBI2Hfl5UrDg9_AdohC5C-MJ4RgrMztGIkpJyKtgYvS2Ub3eZ6qGzKhWT9eB6FVWbdc7X1ti4y2yfwU_00EFCW7fNauvjKt-C_VzFbO0hgu8S1ag-hkt01qg2wNWhTtDH4-J9_pwvX59e5g_LXFPOY05NUxuakoAmmAPDYDiuh8cKyrQAXvMZx6YqldbCFAXUWGhdlQ0mWnNDJ-h2v3ft3fcGQpSdDRraNmVxmyBnlDCWNpQioWyPau9C8NDItbed8jtJsBxsyqNNOdiUB5tp7uZwYlN3YP6mjvoScL8HUnbnO7V1vjUyql3rfONVr21I8L83fgHJlYUm</recordid><startdate>20211117</startdate><enddate>20211117</enddate><creator>Rocha, Gustavo</creator><creator>Pereira, Sandra</creator><creator>Antunes-Sarmento, João</creator><creator>Flôr-de-Lima, Filipa</creator><creator>Soares, Henrique</creator><creator>Guimarães, Hercília</creator><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20211117</creationdate><title>Early anemia and neonatal morbidity in extremely low birth-weight preterm infants</title><author>Rocha, Gustavo ; Pereira, Sandra ; Antunes-Sarmento, João ; Flôr-de-Lima, Filipa ; Soares, Henrique ; Guimarães, Hercília</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c366t-3dfbd3080ec106e50ed60b0b0b5435c8e6b6260d97acc8d44eb08cc97f01cc6d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Anemia</topic><topic>Anemia - epidemiology</topic><topic>Ductus Arteriosus, Patent</topic><topic>extremely low birth-weight infant</topic><topic>Humans</topic><topic>Infant, Extremely Low Birth Weight</topic><topic>Infant, Newborn</topic><topic>Infant, Premature</topic><topic>intraventricular hemorrhage</topic><topic>Morbidity</topic><topic>newborn</topic><topic>packed red blood cells transfusion</topic><topic>patent ductus arteriosus</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rocha, Gustavo</creatorcontrib><creatorcontrib>Pereira, Sandra</creatorcontrib><creatorcontrib>Antunes-Sarmento, João</creatorcontrib><creatorcontrib>Flôr-de-Lima, Filipa</creatorcontrib><creatorcontrib>Soares, Henrique</creatorcontrib><creatorcontrib>Guimarães, Hercília</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of maternal-fetal & neonatal medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rocha, Gustavo</au><au>Pereira, Sandra</au><au>Antunes-Sarmento, João</au><au>Flôr-de-Lima, Filipa</au><au>Soares, Henrique</au><au>Guimarães, Hercília</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Early anemia and neonatal morbidity in extremely low birth-weight preterm infants</atitle><jtitle>The journal of maternal-fetal & neonatal medicine</jtitle><addtitle>J Matern Fetal Neonatal Med</addtitle><date>2021-11-17</date><risdate>2021</risdate><volume>34</volume><issue>22</issue><spage>3697</spage><epage>3703</epage><pages>3697-3703</pages><issn>1476-7058</issn><eissn>1476-4954</eissn><abstract>Extremely low birth-weight (ELBW) preterm infants remain at high risk for mortality and major morbidities, and nearly all need packed red blood cell transfusions within their first weeks of life. The overall objective of this study was to assess the association between anemia at admission to neonatal intensive care unit (NICU) with the neonatal morbidity and mortality in ELBW infants.
This retrospective study was conducted on 106 patients with ELBW admitted at our level III NICU from January 2006 to December 2015. The subjects were divided into two groups: (1) patients with anemia at admission and (2) patients without anemia. Their characteristics and outcomes were compared. Statistical analysis was performed using the Statistical Package for the Social Sciences software, version 24.0 (IBM New York, USA), and a value of p < 0.05 was considered statistically significant.
Of the 106 ELBW, 34 (32%) presented with anemia at admission and 72 (68%) without anemia. Anemia-naive presented mean hemoglobin at the admission of 12.8 ± 1.5 g/dl and nonanemic 16.8 ± 2.1 g/dl, p < .001). The anemic group presented a lower gestational age (26 ± 2 vs. 27 ± 2 SD weeks, p = .025), greater need for inotropic support (52.9 vs. 31.9%, p = .041), longer period of invasive mechanical ventilation (9 vs. 2 days, p = .012), higher FiO
2
need (0.8 vs. 0.4, p < .001), more frequent hemodynamically significant patent ductus arteriosus (HS-PDA) (64.7 vs. 41.7%, p = .006) and severe intra-periventricular hemorrhage (IPVH) (41.2 vs. 16.7%, p = 0.005). The multivariate analysis confirmed an association between anemia at admission and HS-PDA (OR = 3.2; 95% CI: 1.1-9.5, p = 0.044) and severe IPVH (OR = 3.3; 95% CI: 1.0-9.9, p = .038). In anemic infants, ionotropic support and IPVH >2 were considered independent factors for mortality.
In this ELBW series, the presence of anemia at admission to the NICU was associated with HS-PDA and severe IPVH. Preventive strategies for early anemia must be encouraged.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>31736385</pmid><doi>10.1080/14767058.2019.1689948</doi><tpages>7</tpages></addata></record> |
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| source | Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list) |
| subjects | Anemia Anemia - epidemiology Ductus Arteriosus, Patent extremely low birth-weight infant Humans Infant, Extremely Low Birth Weight Infant, Newborn Infant, Premature intraventricular hemorrhage Morbidity newborn packed red blood cells transfusion patent ductus arteriosus Retrospective Studies |
| title | Early anemia and neonatal morbidity in extremely low birth-weight preterm infants |
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