Titanium dioxide nanotubes incorporated gellan gum bio-nanocomposite film for wound healing: Effect of TiO 2 nanotubes concentration

The synthesized titanium dioxide nanotubes (TiO -NTs) were emerged as wound healing enhancer as well as exhibited significant wound healing activity on Sprague Dawley rats. In our present study, the blends of GG and TiO -NTs bio-nanocomposite film was characterised by fourier transform infrared (FTI...

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Bibliographic Details
Published in:International journal of biological macromolecules 2020-06, Vol.153, p.1117
Main Authors: Razali, Mohd Hasmizam, Ismail, Nur Arifah, Mat Amin, Khairul Anuar
Format: Article
Language:English
Subjects:
Animals
Biocompatible Materials - chemistry
Biocompatible Materials - pharmacology
Nanocomposites - chemistry
Nanotubes - chemistry
Polysaccharides, Bacterial - chemistry
Rats
Rats, Sprague-Dawley
Structure-Activity Relationship
Titanium - chemistry
Wound Healing - drug effects
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Summary:The synthesized titanium dioxide nanotubes (TiO -NTs) were emerged as wound healing enhancer as well as exhibited significant wound healing activity on Sprague Dawley rats. In our present study, the blends of GG and TiO -NTs bio-nanocomposite film was characterised by fourier transform infrared (FTIR), x-ray diffraction (XRD), scanning electron microscopy (SEM), thermogravimetric analysis, atomic force microscopy (AFM). The morphology of TiO -NTs was investigated using transmission electron microscopy (TEM). The mechanical properties study shows that the GG + TiO -NTs (20 w/w %) bio-nanocomposite film possessed the highest tensile strength and young modulus which are (4.56 ± 0.15) MPa and (68 ± 1.63) MPa, respectively. GG + TiO -NTs (20 w/w %) also displays the highest antibacterial activity with (16 ± 0.06) mm, (16 ± 0.06) mm, (14 ± 0.06) mm, and (12 ± 0.25) mm inhibition zone were recorded against Staphylococcus aureus, Streptococcus, Escherichia coli, and Pseudomonas aeruginosa. The prepared bio-nanocomposite films have good biocompatibility against 3T3 mouse fibroblast cells and caused accelerated healing of open excision type wounds on Sprague Dawley rat model. The synergistic effects of bio-nanocomposite film like good swelling and WVTR properties, excellent hydrophilic nature, biocompatibility, wound appearance and wound closure rate through in vivo test makes it a suitable candidate for wound healing applications.
ISSN:1879-0003