A Clinical Prototype Transrectal Diffuse Optical Tomography (TRDOT) System for In vivo Monitoring of Photothermal Therapy (PTT) of Focal Prostate Cancer

We describe the rationale, design, fabrication and performance of a clinical transrectal diffuse optical tomography (TRDOT) system for in vivo monitoring of photothermal therapy (PTT) of localized prostate cancer. The system comprises a 32-channel fiberoptic-based, MRI-compatible transrectal probe c...

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Bibliographic Details
Published in:IEEE transactions on biomedical engineering 2020-07, Vol.67 (7), p.2119-2129
Main Authors: He, Jie, Li, Celina L., Wilson, Brian C., Fisher, Carl J., Ghai, Sangeet, Weersink, Robert A.
Format: Article
Language:English
Subjects:
Biomedical optical imaging
Clinical trials
Computer simulation
Control equipment
Detectors
Fabrication
In vivo methods and tests
Localized prostate cancer
Magnetic resonance imaging
Monitoring
Muscles
Optical fiber devices
Optical fibers
Optical imaging
Performance tests
Photomultiplier tubes
Photothermal therapy
Probes
Prostate cancer
Semiconductor lasers
Tomography
Transrectal diffuse optical tomography
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Summary:We describe the rationale, design, fabrication and performance of a clinical transrectal diffuse optical tomography (TRDOT) system for in vivo monitoring of photothermal therapy (PTT) of localized prostate cancer. The system comprises a 32-channel fiberoptic-based, MRI-compatible transrectal probe connected to a computer-controlled instrument that includes laser diode sources, an optical fiber switch and photomultiplier tube detectors. Performance tests were performed in tissue-simulating phantoms and in ex vivo muscle tissue during PTT treatment. The safety and technical feasibility of in vivo transrectal use were tested in a canine prostate model and in a first-in-human study in a patient before PTT treatment. Limitations of the system are discussed, as well as further developments to translate it into planned clinical trials for monitoring the photocoagulation boundary in the prostate during PTT.
ISSN:0018-9294
1558-2531
DOI:10.1109/TBME.2019.2955354