The Effect of n -3 PUFA Binding Phosphatidylglycerol on Metabolic Syndrome-Related Parameters and n -3 PUFA Accretion in Diabetic/Obese KK- A y Mice

• Published in: Nutrients 2019-11, Vol.11 (12)
• Main Authors: Chen, Liping, Takatani, Naoki, Beppu, Fumiaki, Miyashita, Kazuo, Hosokawa, Masashi
• Format: Article
• Language: English
• ISSN: 2072-6643

-3 Polyunsaturated fatty acid binding phospholipids ( -3 PUFA-PLs) are known to be potent carriers of -3 PUFAs and provide health benefits. We previously prepared -3 PUFA binding phosphatidylglycerol ( -3 PUFA-PG) by phospholipase D-mediated transphosphatidylation. Because PG has excellent emulsifiability, -3 PUFA-PG is expected to work as a functional molecule with properties of both PG and -3 PUFAs. In the present study, the health benefits and tissue accretion of dietary -3 PUFA-PG were examined in diabetic/obese KK- mice. After a feeding duration over 30 days, -3 PUFA-PG significantly reduced the total and non-HDL cholesterols in the serum of diabetic/obese KK- mice. In the mice fed -3 PUFA-PG, but not -3 PUFA-TAG, hepatic lipid content was markedly alleviated depending on the neutral lipid reduction compared with the SoyPC-fed mice. Further, the -3 PUFA-PG diet increased eicosapentaenoic acid and docosahexaenoic acid (DHA) and reduced arachidonic acid in the small intestine, liver, perirenal white adipose tissue, and brain, and the ratio of the n-6 PUFAs to -3 PUFAs in those tissues became lower compared to the SoyPC-fed mice. Especially, the DHA level was more significantly elevated in the brains of -3 PUFA-PG-fed mice compared to the SoyPC-fed mice, whereas -3 PUFA-TAG did not significantly alter DHA in the brain. The present results indicate that -3 PUFA-PG is a functional lipid for reducing serum and liver lipids and is able to supply -3 PUFAs to KK- mice.