Effect of a New Synthetic Peptide Preparation AСTH 15-18 PGP on the Hemostasis System in Rats

We studied the effect of chronic intranasal and peroral administration of a new peptide preparation AСTH PGP in a dose of 100 mg/kg body weight on the state of vascular-platelet and plasma hemostasis in animals. It was found that this synthetic regulatory peptide administered intranasally can produc...

Full description

Saved in:
Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2019-12, Vol.168 (2), p.250
Main Authors: Shubina, T A, Obergan, T Yu, Lyapina, L A, Grigorieva, M E, Myasoedov, N F, Andreeva, L A
Format: Article
Language:English
Subjects:
Adrenocorticotropic Hormone - analogs & derivatives
Adrenocorticotropic Hormone - pharmacology
Animals
Anticoagulants - pharmacology
Blood Coagulation - drug effects
Blood Platelets - drug effects
Fibrinolysis - drug effects
Hemostasis - drug effects
Male
Oligopeptides - pharmacology
Platelet Aggregation Inhibitors - pharmacology
Proline - analogs & derivatives
Proline - pharmacology
Rats
Rats, Wistar
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We studied the effect of chronic intranasal and peroral administration of a new peptide preparation AСTH PGP in a dose of 100 mg/kg body weight on the state of vascular-platelet and plasma hemostasis in animals. It was found that this synthetic regulatory peptide administered intranasally can produce antiplatelet, anticoagulant, and antifibrin-stabilizing effects on the blood plasma in healthy rats. In both administration routes, the peptide induced activation of the anticoagulation system of the hemostasis by increasing enzymatic and non-enzymatic fibrinolysis; after intranasal administration, the fibrinolytic effects were more pronounced.
ISSN:1573-8221