Plasma total calcium concentration is associated with blood pressure and systemic vascular resistance in normotensive and never-treated hypertensive subjects

Purpose: The underlying causes of primary hypertension are not fully understood. Evidence on the relation of plasma calcium concentration with blood pressure (BP) is inconsistent and relies largely on studies utilizing office BP measurements in populations using cardiovascular drugs. In many studies...

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Bibliographic Details
Published in:Blood pressure 2020-05, Vol.29 (3), p.137-148
Main Authors: Oinonen, Lasse, Koskela, Jenni, Eräranta, Arttu, Tikkakoski, Antti, Kähönen, Mika, Niemelä, Onni, Mustonen, Jukka, Pörsti, Ilkka
Format: Article
Language:English
Subjects:
Adult
Aged
Biomarkers - blood
Blood Pressure
Calcium - blood
Case-Control Studies
Cross-Sectional Studies
Female
haemodynamics
Humans
Hypertension - blood
Hypertension - diagnosis
Hypertension - physiopathology
Male
Middle Aged
Plasma calcium
Risk Factors
systemic vascular resistance
Up-Regulation
Vascular Resistance
Young Adult
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Summary:Purpose: The underlying causes of primary hypertension are not fully understood. Evidence on the relation of plasma calcium concentration with blood pressure (BP) is inconsistent and relies largely on studies utilizing office BP measurements in populations using cardiovascular drugs. In many studies adjustment for confounders was not optimal. In this cross-sectional study we examined the association of plasma total calcium concentration with the haemodynamic determinants of blood pressure. Subjects and methods: Supine haemodynamics were recorded using pulse wave analysis, whole-body impedance cardiography, and heart rate variability analysis in 618 normotensive or never-treated hypertensive subjects (aged 19-72 years) without diabetes, cardiovascular or renal disease, or cardiovascular medications. Linear regression analysis was used to investigate factors associated with haemodynamic variables. Results: Mean age was 45.0 years, body mass index 26.8 kg/m 2 , seated office BP 141/89 mmHg, and 307 subjects (49.7%) were male. Mean values of routine blood and plasma chemistry analyses were within the reference limits of the tests except for low-density lipoprotein cholesterol (3.05 mmol/l). In the laboratory, mean supine radial BP was 131/75 mmHg, and both systolic and diastolic BP correlated directly with plasma total calcium concentration (r = 0.25 and r = 0.22, respectively, p 
ISSN:0803-7051
1651-1999
DOI:10.1080/08037051.2019.1696180