Chemical constituents from Schisandra sphenanthera and their cytotoxic activity

Extensive phytochemical investigation of Schisandra sphenanthera leaves resulted in the isolation of six highly oxygenated nortriterpenoids (1-6) and five lignans (7-11) including a new pre-schisanartane-type, schisandrathera A (1), a new dibenzocyclooctadiene glycoside, schisandrathera B (7) and tw...

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Bibliographic Details
Published in:Natural product research 2021-10, Vol.35 (20), p.3360-3369
Main Authors: Mai, Nguyen Thi, Doan, Vu Van, Lan, Hoang Thi Tuyet, Anh, Bui Thi Mai, Hoang, Nguyen Huy, Tai, Bui Huu, Nhiem, Nguyen Xuan, Yen, Pham Hai, Park, Seon Ju, Seo, Yohan, Namkung, Wan, Kim, Seung Hyun, Kiem, Phan Van
Format: Article
Language:English
Subjects:
Antineoplastic Agents, Phytogenic - isolation & purification
Antineoplastic Agents, Phytogenic - pharmacology
Humans
Lignans - isolation & purification
Lignans - pharmacology
MCF-7 Cells
Plant Leaves - chemistry
Schisandra - chemistry
Schisandra sphenanthera
Schisandraceae
schisandrathera A
schisandrathera B
schisandrathera C
schisandrathera D
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Summary:Extensive phytochemical investigation of Schisandra sphenanthera leaves resulted in the isolation of six highly oxygenated nortriterpenoids (1-6) and five lignans (7-11) including a new pre-schisanartane-type, schisandrathera A (1), a new dibenzocyclooctadiene glycoside, schisandrathera B (7) and two new lignans, schisandrathera C (8) and schisandrathera D (9). Their chemical structures including absolute configurations were determined extensively by means of HR-ESI-MS, NMR, and ECD spectra. In addition, all isolated compounds were tested for cytotoxic activity against PC3 (prostate cancer) and MCF7 (breast cancer) cell lines. Among these compounds, schirubrisin B (3) showed strong cytotoxic effect on both PC3 and MCF7 cell lines with IC 50 values of 3.21 ± 0.68, 13.30 ± 0.68 μM, respectively, whereas ten remaining compounds were found to be less effective in the investigated models.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2019.1700247