Development of galangal essential oil-based microemulsion gel for transdermal delivery of flurbiprofen: simultaneous permeability evaluation of flurbiprofen and 1,8-cineole

Flurbiprofen (FP) is one of the most potent nonsteroidal anti-inflammatory drugs with very low bioavailability of approximately 12% following transdermal administration, compared to that after oral administration. This study aimed to deliver FP as a microemulsion (ME) gel by transdermal administrati...

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Bibliographic Details
Published in:Drug development and industrial pharmacy 2020-01, Vol.46 (1), p.91-100
Main Authors: Dong, Jie, Zhu, Xue-min, Wu, Feng-ye, Yang, Bing-qing, Feng, Han, Dong, Yun-fei, Gu, Wei, Chen, Jun
Format: Article
Language:English
Subjects:
1,8-cineole
anti-inflammatory effect
flurbiprofen
galangal essential oil
microemulsion gel
pharmacokinetics
transdermal
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Summary:Flurbiprofen (FP) is one of the most potent nonsteroidal anti-inflammatory drugs with very low bioavailability of approximately 12% following transdermal administration, compared to that after oral administration. This study aimed to deliver FP as a microemulsion (ME) gel by transdermal administration. Galangal essential oil (GEO) was extracted from Rhizoma Alpiniae Officinarum and identified by GC-MS. The most abundant constituent was determined to be 1,8-cineole (52.06%). Compared to azone, GEO was proved to exert significantly higher (p 
ISSN:0363-9045
1520-5762
DOI:10.1080/03639045.2019.1706548