Loading…
Valproate reverses stress-induced somatic hyperalgesia and visceral hypersensitivity by up-regulating spinal 5-HT 2C receptor expression in female rats
Sodium valproate (VPA) has analgesic effects in clinical and experimental studies, but the mechanisms are still unclear. The present study examined the effects of VPA on stress-induced somatic hyperalgesia and visceral hypersensitivity and the role of 5-HT receptors in the spinal cord. Repeated 3 da...
Saved in:
| Published in: | Neuropharmacology 2020-03, Vol.165, p.107926 |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | |
|---|---|
| cites | |
| container_end_page | |
| container_issue | |
| container_start_page | 107926 |
| container_title | Neuropharmacology |
| container_volume | 165 |
| creator | Xu, Gang-Zhu Xue, Yang Wei, Si-Qi Li, Jia-Heng Traub, Richard J Wang, Mao-De Cao, Dong-Yuan |
| description | Sodium valproate (VPA) has analgesic effects in clinical and experimental studies, but the mechanisms are still unclear. The present study examined the effects of VPA on stress-induced somatic hyperalgesia and visceral hypersensitivity and the role of 5-HT
receptors in the spinal cord. Repeated 3 day forced swim (FS) significantly reduced the thermal withdrawal latency and mechanical withdrawal threshold, and increased the magnitude of the visceromotor response to colorectal distention compared to the baseline values in rats. The somatic hyperalgesia and visceral hypersensitivity were accompanied by significant down-regulation of 5-HT
receptor expression in the L4-L5 and L6-S1 dorsal spinal cord. Intraperitoneal administration of VPA (300 mg/kg) before each FS and 1 day post FS prevented the development of somatic hyperalgesia and visceral hypersensitivity induced by FS stress, as well as down-regulation of 5-HT
receptors in the spinal cord. The reversal of somatic hyperalgesia and visceral hypersensitivity by VPA in FS rats was blocked by intrathecal administration of the selective 5-HT
receptor antagonist RS-102221 (30 μg/10 μL) 30 min after each VPA injection. The results suggest that VPA attenuates FS-induced somatic hyperalgesia and visceral hypersensitivity by restoring down-regulated function of 5-HT
receptors in the spinal cord. |
| doi_str_mv | 10.1016/j.neuropharm.2019.107926 |
| format | article |
| fullrecord | <record><control><sourceid>pubmed</sourceid><recordid>TN_cdi_pubmed_primary_31883927</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>31883927</sourcerecordid><originalsourceid>FETCH-pubmed_primary_318839273</originalsourceid><addsrcrecordid>eNqFT1tOwzAQtJAQLY8roL1Agp2UPL4rUA9Q8Vttk23qKnGsXSciJ-G6uAK--RppHpoZpcDo1GhTvFxSRxOP_ow8pJk2daTLOitu1NpUZZ6Uutis1L3IRWu9qUx1p1a5qaq8zsq1-vrA3vOIgYBpJhYSkMAkkljXTg21IOOAwTZwXjwx9h2JRUDXwmyluTI_ipATG-xswwLHBSafMHVTH6OuA_HWReNrsttDto1VDfkwMtCnv3bZ0YF1cKIB-zgEgzyq2xP2Qk-_-KCe39_2213ip-NA7cGzHZCXw9-T_F_DNzFWYOo</addsrcrecordid><sourcetype>Index Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Valproate reverses stress-induced somatic hyperalgesia and visceral hypersensitivity by up-regulating spinal 5-HT 2C receptor expression in female rats</title><source>ScienceDirect Journals</source><creator>Xu, Gang-Zhu ; Xue, Yang ; Wei, Si-Qi ; Li, Jia-Heng ; Traub, Richard J ; Wang, Mao-De ; Cao, Dong-Yuan</creator><creatorcontrib>Xu, Gang-Zhu ; Xue, Yang ; Wei, Si-Qi ; Li, Jia-Heng ; Traub, Richard J ; Wang, Mao-De ; Cao, Dong-Yuan</creatorcontrib><description>Sodium valproate (VPA) has analgesic effects in clinical and experimental studies, but the mechanisms are still unclear. The present study examined the effects of VPA on stress-induced somatic hyperalgesia and visceral hypersensitivity and the role of 5-HT
receptors in the spinal cord. Repeated 3 day forced swim (FS) significantly reduced the thermal withdrawal latency and mechanical withdrawal threshold, and increased the magnitude of the visceromotor response to colorectal distention compared to the baseline values in rats. The somatic hyperalgesia and visceral hypersensitivity were accompanied by significant down-regulation of 5-HT
receptor expression in the L4-L5 and L6-S1 dorsal spinal cord. Intraperitoneal administration of VPA (300 mg/kg) before each FS and 1 day post FS prevented the development of somatic hyperalgesia and visceral hypersensitivity induced by FS stress, as well as down-regulation of 5-HT
receptors in the spinal cord. The reversal of somatic hyperalgesia and visceral hypersensitivity by VPA in FS rats was blocked by intrathecal administration of the selective 5-HT
receptor antagonist RS-102221 (30 μg/10 μL) 30 min after each VPA injection. The results suggest that VPA attenuates FS-induced somatic hyperalgesia and visceral hypersensitivity by restoring down-regulated function of 5-HT
receptors in the spinal cord.</description><identifier>EISSN: 1873-7064</identifier><identifier>DOI: 10.1016/j.neuropharm.2019.107926</identifier><identifier>PMID: 31883927</identifier><language>eng</language><publisher>England</publisher><subject>Analgesics - administration & dosage ; Animals ; Female ; Hyperalgesia - etiology ; Hyperalgesia - metabolism ; Hyperalgesia - prevention & control ; Rats, Sprague-Dawley ; Receptor, Serotonin, 5-HT2C - metabolism ; Stress, Psychological - complications ; Up-Regulation ; Valproic Acid - administration & dosage</subject><ispartof>Neuropharmacology, 2020-03, Vol.165, p.107926</ispartof><rights>Copyright © 2019 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31883927$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xu, Gang-Zhu</creatorcontrib><creatorcontrib>Xue, Yang</creatorcontrib><creatorcontrib>Wei, Si-Qi</creatorcontrib><creatorcontrib>Li, Jia-Heng</creatorcontrib><creatorcontrib>Traub, Richard J</creatorcontrib><creatorcontrib>Wang, Mao-De</creatorcontrib><creatorcontrib>Cao, Dong-Yuan</creatorcontrib><title>Valproate reverses stress-induced somatic hyperalgesia and visceral hypersensitivity by up-regulating spinal 5-HT 2C receptor expression in female rats</title><title>Neuropharmacology</title><addtitle>Neuropharmacology</addtitle><description>Sodium valproate (VPA) has analgesic effects in clinical and experimental studies, but the mechanisms are still unclear. The present study examined the effects of VPA on stress-induced somatic hyperalgesia and visceral hypersensitivity and the role of 5-HT
receptors in the spinal cord. Repeated 3 day forced swim (FS) significantly reduced the thermal withdrawal latency and mechanical withdrawal threshold, and increased the magnitude of the visceromotor response to colorectal distention compared to the baseline values in rats. The somatic hyperalgesia and visceral hypersensitivity were accompanied by significant down-regulation of 5-HT
receptor expression in the L4-L5 and L6-S1 dorsal spinal cord. Intraperitoneal administration of VPA (300 mg/kg) before each FS and 1 day post FS prevented the development of somatic hyperalgesia and visceral hypersensitivity induced by FS stress, as well as down-regulation of 5-HT
receptors in the spinal cord. The reversal of somatic hyperalgesia and visceral hypersensitivity by VPA in FS rats was blocked by intrathecal administration of the selective 5-HT
receptor antagonist RS-102221 (30 μg/10 μL) 30 min after each VPA injection. The results suggest that VPA attenuates FS-induced somatic hyperalgesia and visceral hypersensitivity by restoring down-regulated function of 5-HT
receptors in the spinal cord.</description><subject>Analgesics - administration & dosage</subject><subject>Animals</subject><subject>Female</subject><subject>Hyperalgesia - etiology</subject><subject>Hyperalgesia - metabolism</subject><subject>Hyperalgesia - prevention & control</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptor, Serotonin, 5-HT2C - metabolism</subject><subject>Stress, Psychological - complications</subject><subject>Up-Regulation</subject><subject>Valproic Acid - administration & dosage</subject><issn>1873-7064</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNqFT1tOwzAQtJAQLY8roL1Agp2UPL4rUA9Q8Vttk23qKnGsXSciJ-G6uAK--RppHpoZpcDo1GhTvFxSRxOP_ow8pJk2daTLOitu1NpUZZ6Uutis1L3IRWu9qUx1p1a5qaq8zsq1-vrA3vOIgYBpJhYSkMAkkljXTg21IOOAwTZwXjwx9h2JRUDXwmyluTI_ipATG-xswwLHBSafMHVTH6OuA_HWReNrsttDto1VDfkwMtCnv3bZ0YF1cKIB-zgEgzyq2xP2Qk-_-KCe39_2213ip-NA7cGzHZCXw9-T_F_DNzFWYOo</recordid><startdate>20200315</startdate><enddate>20200315</enddate><creator>Xu, Gang-Zhu</creator><creator>Xue, Yang</creator><creator>Wei, Si-Qi</creator><creator>Li, Jia-Heng</creator><creator>Traub, Richard J</creator><creator>Wang, Mao-De</creator><creator>Cao, Dong-Yuan</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>20200315</creationdate><title>Valproate reverses stress-induced somatic hyperalgesia and visceral hypersensitivity by up-regulating spinal 5-HT 2C receptor expression in female rats</title><author>Xu, Gang-Zhu ; Xue, Yang ; Wei, Si-Qi ; Li, Jia-Heng ; Traub, Richard J ; Wang, Mao-De ; Cao, Dong-Yuan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-pubmed_primary_318839273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Analgesics - administration & dosage</topic><topic>Animals</topic><topic>Female</topic><topic>Hyperalgesia - etiology</topic><topic>Hyperalgesia - metabolism</topic><topic>Hyperalgesia - prevention & control</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptor, Serotonin, 5-HT2C - metabolism</topic><topic>Stress, Psychological - complications</topic><topic>Up-Regulation</topic><topic>Valproic Acid - administration & dosage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xu, Gang-Zhu</creatorcontrib><creatorcontrib>Xue, Yang</creatorcontrib><creatorcontrib>Wei, Si-Qi</creatorcontrib><creatorcontrib>Li, Jia-Heng</creatorcontrib><creatorcontrib>Traub, Richard J</creatorcontrib><creatorcontrib>Wang, Mao-De</creatorcontrib><creatorcontrib>Cao, Dong-Yuan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Neuropharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xu, Gang-Zhu</au><au>Xue, Yang</au><au>Wei, Si-Qi</au><au>Li, Jia-Heng</au><au>Traub, Richard J</au><au>Wang, Mao-De</au><au>Cao, Dong-Yuan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Valproate reverses stress-induced somatic hyperalgesia and visceral hypersensitivity by up-regulating spinal 5-HT 2C receptor expression in female rats</atitle><jtitle>Neuropharmacology</jtitle><addtitle>Neuropharmacology</addtitle><date>2020-03-15</date><risdate>2020</risdate><volume>165</volume><spage>107926</spage><pages>107926-</pages><eissn>1873-7064</eissn><abstract>Sodium valproate (VPA) has analgesic effects in clinical and experimental studies, but the mechanisms are still unclear. The present study examined the effects of VPA on stress-induced somatic hyperalgesia and visceral hypersensitivity and the role of 5-HT
receptors in the spinal cord. Repeated 3 day forced swim (FS) significantly reduced the thermal withdrawal latency and mechanical withdrawal threshold, and increased the magnitude of the visceromotor response to colorectal distention compared to the baseline values in rats. The somatic hyperalgesia and visceral hypersensitivity were accompanied by significant down-regulation of 5-HT
receptor expression in the L4-L5 and L6-S1 dorsal spinal cord. Intraperitoneal administration of VPA (300 mg/kg) before each FS and 1 day post FS prevented the development of somatic hyperalgesia and visceral hypersensitivity induced by FS stress, as well as down-regulation of 5-HT
receptors in the spinal cord. The reversal of somatic hyperalgesia and visceral hypersensitivity by VPA in FS rats was blocked by intrathecal administration of the selective 5-HT
receptor antagonist RS-102221 (30 μg/10 μL) 30 min after each VPA injection. The results suggest that VPA attenuates FS-induced somatic hyperalgesia and visceral hypersensitivity by restoring down-regulated function of 5-HT
receptors in the spinal cord.</abstract><cop>England</cop><pmid>31883927</pmid><doi>10.1016/j.neuropharm.2019.107926</doi></addata></record> |
| fulltext | fulltext |
| identifier | EISSN: 1873-7064 |
| ispartof | Neuropharmacology, 2020-03, Vol.165, p.107926 |
| issn | 1873-7064 |
| language | eng |
| recordid | cdi_pubmed_primary_31883927 |
| source | ScienceDirect Journals |
| subjects | Analgesics - administration & dosage Animals Female Hyperalgesia - etiology Hyperalgesia - metabolism Hyperalgesia - prevention & control Rats, Sprague-Dawley Receptor, Serotonin, 5-HT2C - metabolism Stress, Psychological - complications Up-Regulation Valproic Acid - administration & dosage |
| title | Valproate reverses stress-induced somatic hyperalgesia and visceral hypersensitivity by up-regulating spinal 5-HT 2C receptor expression in female rats |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T17%3A20%3A24IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Valproate%20reverses%20stress-induced%20somatic%20hyperalgesia%20and%20visceral%20hypersensitivity%20by%20up-regulating%20spinal%205-HT%202C%20receptor%20expression%20in%20female%20rats&rft.jtitle=Neuropharmacology&rft.au=Xu,%20Gang-Zhu&rft.date=2020-03-15&rft.volume=165&rft.spage=107926&rft.pages=107926-&rft.eissn=1873-7064&rft_id=info:doi/10.1016/j.neuropharm.2019.107926&rft_dat=%3Cpubmed%3E31883927%3C/pubmed%3E%3Cgrp_id%3Ecdi_FETCH-pubmed_primary_318839273%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_id=info:pmid/31883927&rfr_iscdi=true |