Neonicotinoid Insecticides: Molecular Targets, Resistance, and Toxicity

Neonicotinoids have been used to protect crops and animals from insect pests since the 1990s, but there are concerns regarding their adverse effects on nontarget organisms, notably on bees. Enhanced resistance to neonicotinoids in pests is becoming well documented. We address the current understandi...

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Bibliographic Details
Published in:Annual review of pharmacology and toxicology 2020-01, Vol.60 (1), p.241-255
Main Authors: Matsuda, Kazuhiko, Ihara, Makoto, Sattelle, David B
Format: Article
Language:English
Subjects:
ion channels
neonicotinoids
nicotinic acetylcholine receptors
pollinators
resistance
selective toxicity
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Summary:Neonicotinoids have been used to protect crops and animals from insect pests since the 1990s, but there are concerns regarding their adverse effects on nontarget organisms, notably on bees. Enhanced resistance to neonicotinoids in pests is becoming well documented. We address the current understanding of neonicotinoid target site interactions, selectivity, and metabolism not only in pests but also in beneficial insects such as bees. The findings are relevant to the management of both neonicotinoids and the new generation of pesticides targeting insect nicotinic acetylcholine receptors.
ISSN:0362-1642
1545-4304
DOI:10.1146/annurev-pharmtox-010818-021747