Biotinylated photoactive Pt() anticancer complexes

Novel biotinylated diazido-Pt( iv ) complexes exhibit high visible light photocytotoxicity while being stable in the dark. Photocytotoxicity and cellular accumulation of all- trans -[Pt(py) 2 (N 3 ) 2 (biotin)(OH)] ( 2a ) were enhanced significantly when bound to avidin; irradiation induced dramatic...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2020-02, Vol.56 (15), p.232-2323
Main Authors: Shi, Huayun, Imberti, Cinzia, Huang, Huaiyi, Hands-Portman, Ian, Sadler, Peter J
Format: Article
Language:English
Subjects:
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Biotin
Biotinylation
Cell Line, Tumor
Cell Proliferation - drug effects
Decomposition reactions
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Female
Humans
Molecular Structure
NMR
Nuclear magnetic resonance
Optical Imaging
Organoplatinum Compounds - chemical synthesis
Organoplatinum Compounds - chemistry
Organoplatinum Compounds - pharmacology
Ovarian Neoplasms - diagnostic imaging
Ovarian Neoplasms - drug therapy
Ovarian Neoplasms - pathology
Photochemical Processes
Photodecomposition
Structure-Activity Relationship
Titration
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Summary:Novel biotinylated diazido-Pt( iv ) complexes exhibit high visible light photocytotoxicity while being stable in the dark. Photocytotoxicity and cellular accumulation of all- trans -[Pt(py) 2 (N 3 ) 2 (biotin)(OH)] ( 2a ) were enhanced significantly when bound to avidin; irradiation induced dramatic cellular morphological changes in human ovarian cancer cells treated with 2a . Novel biotinylated diazido-Pt( iv ) complexes exhibit high visible light photocytotoxicity while being stable in the dark.
ISSN:1359-7345
1364-548X
DOI:10.1039/c9cc07845b