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Biotinylated photoactive Pt() anticancer complexes
Novel biotinylated diazido-Pt( iv ) complexes exhibit high visible light photocytotoxicity while being stable in the dark. Photocytotoxicity and cellular accumulation of all- trans -[Pt(py) 2 (N 3 ) 2 (biotin)(OH)] ( 2a ) were enhanced significantly when bound to avidin; irradiation induced dramatic...
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| Published in: | Chemical communications (Cambridge, England) England), 2020-02, Vol.56 (15), p.232-2323 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c414t-27efff7461acdde0644d6900172443397b109687da7e1251578f288768ad506b3 |
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| cites | cdi_FETCH-LOGICAL-c414t-27efff7461acdde0644d6900172443397b109687da7e1251578f288768ad506b3 |
| container_end_page | 2323 |
| container_issue | 15 |
| container_start_page | 232 |
| container_title | Chemical communications (Cambridge, England) |
| container_volume | 56 |
| creator | Shi, Huayun Imberti, Cinzia Huang, Huaiyi Hands-Portman, Ian Sadler, Peter J |
| description | Novel biotinylated diazido-Pt(
iv
) complexes exhibit high visible light photocytotoxicity while being stable in the dark. Photocytotoxicity and cellular accumulation of all-
trans
-[Pt(py)
2
(N
3
)
2
(biotin)(OH)] (
2a
) were enhanced significantly when bound to avidin; irradiation induced dramatic cellular morphological changes in human ovarian cancer cells treated with
2a
.
Novel biotinylated diazido-Pt(
iv
) complexes exhibit high visible light photocytotoxicity while being stable in the dark. |
| doi_str_mv | 10.1039/c9cc07845b |
| format | article |
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iv
) complexes exhibit high visible light photocytotoxicity while being stable in the dark. Photocytotoxicity and cellular accumulation of all-
trans
-[Pt(py)
2
(N
3
)
2
(biotin)(OH)] (
2a
) were enhanced significantly when bound to avidin; irradiation induced dramatic cellular morphological changes in human ovarian cancer cells treated with
2a
.
Novel biotinylated diazido-Pt(
iv
) complexes exhibit high visible light photocytotoxicity while being stable in the dark.</description><identifier>ISSN: 1359-7345</identifier><identifier>EISSN: 1364-548X</identifier><identifier>DOI: 10.1039/c9cc07845b</identifier><identifier>PMID: 31990000</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Antineoplastic Agents - chemical synthesis ; Antineoplastic Agents - chemistry ; Antineoplastic Agents - pharmacology ; Biotin ; Biotinylation ; Cell Line, Tumor ; Cell Proliferation - drug effects ; Decomposition reactions ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Female ; Humans ; Molecular Structure ; NMR ; Nuclear magnetic resonance ; Optical Imaging ; Organoplatinum Compounds - chemical synthesis ; Organoplatinum Compounds - chemistry ; Organoplatinum Compounds - pharmacology ; Ovarian Neoplasms - diagnostic imaging ; Ovarian Neoplasms - drug therapy ; Ovarian Neoplasms - pathology ; Photochemical Processes ; Photodecomposition ; Structure-Activity Relationship ; Titration</subject><ispartof>Chemical communications (Cambridge, England), 2020-02, Vol.56 (15), p.232-2323</ispartof><rights>Copyright Royal Society of Chemistry 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c414t-27efff7461acdde0644d6900172443397b109687da7e1251578f288768ad506b3</citedby><cites>FETCH-LOGICAL-c414t-27efff7461acdde0644d6900172443397b109687da7e1251578f288768ad506b3</cites><orcidid>0000-0002-8895-2342 ; 0000-0003-1187-7951 ; 0000-0002-2091-7954 ; 0000-0001-9160-1941 ; 0000-0003-2334-7886</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31990000$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shi, Huayun</creatorcontrib><creatorcontrib>Imberti, Cinzia</creatorcontrib><creatorcontrib>Huang, Huaiyi</creatorcontrib><creatorcontrib>Hands-Portman, Ian</creatorcontrib><creatorcontrib>Sadler, Peter J</creatorcontrib><title>Biotinylated photoactive Pt() anticancer complexes</title><title>Chemical communications (Cambridge, England)</title><addtitle>Chem Commun (Camb)</addtitle><description>Novel biotinylated diazido-Pt(
iv
) complexes exhibit high visible light photocytotoxicity while being stable in the dark. Photocytotoxicity and cellular accumulation of all-
trans
-[Pt(py)
2
(N
3
)
2
(biotin)(OH)] (
2a
) were enhanced significantly when bound to avidin; irradiation induced dramatic cellular morphological changes in human ovarian cancer cells treated with
2a
.
Novel biotinylated diazido-Pt(
iv
) complexes exhibit high visible light photocytotoxicity while being stable in the dark.</description><subject>Antineoplastic Agents - chemical synthesis</subject><subject>Antineoplastic Agents - chemistry</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Biotin</subject><subject>Biotinylation</subject><subject>Cell Line, Tumor</subject><subject>Cell Proliferation - drug effects</subject><subject>Decomposition reactions</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Screening Assays, Antitumor</subject><subject>Female</subject><subject>Humans</subject><subject>Molecular Structure</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Optical Imaging</subject><subject>Organoplatinum Compounds - chemical synthesis</subject><subject>Organoplatinum Compounds - chemistry</subject><subject>Organoplatinum Compounds - pharmacology</subject><subject>Ovarian Neoplasms - diagnostic imaging</subject><subject>Ovarian Neoplasms - drug therapy</subject><subject>Ovarian Neoplasms - pathology</subject><subject>Photochemical Processes</subject><subject>Photodecomposition</subject><subject>Structure-Activity Relationship</subject><subject>Titration</subject><issn>1359-7345</issn><issn>1364-548X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNpFkE1Lw0AQhhdRbK1evCsBLypEd7Pfxzb4BQU9KHgLm90NpqTZuLsV--9NTa1zmRnmYV54ADhF8AZBLG-11BpyQWi5B8YIM5JSIt73NzOVKceEjsBRCAvYF6LiEIwwknKzjUE2q12s23WjojVJ9-GiUzrWXzZ5iZdXiWpjrVWrrU-0W3aN_bbhGBxUqgn2ZNsn4O3-7jV_TOfPD0_5dJ5qgkhMM26rquKEIaWNsZARYlifinhGCMaSlwhKJrhR3KKMIspFlQnBmVCGQlbiCbgY_nbefa5siMXCrXzbRxYZpoJAJInoqeuB0t6F4G1VdL5eKr8uECw2eopc5vmvnlkPn29frsqlNTv0z0cPnA2AD3p3_feLfwCx7Wc4</recordid><startdate>20200221</startdate><enddate>20200221</enddate><creator>Shi, Huayun</creator><creator>Imberti, Cinzia</creator><creator>Huang, Huaiyi</creator><creator>Hands-Portman, Ian</creator><creator>Sadler, Peter J</creator><general>Royal Society of Chemistry</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><orcidid>https://orcid.org/0000-0002-8895-2342</orcidid><orcidid>https://orcid.org/0000-0003-1187-7951</orcidid><orcidid>https://orcid.org/0000-0002-2091-7954</orcidid><orcidid>https://orcid.org/0000-0001-9160-1941</orcidid><orcidid>https://orcid.org/0000-0003-2334-7886</orcidid></search><sort><creationdate>20200221</creationdate><title>Biotinylated photoactive Pt() anticancer complexes</title><author>Shi, Huayun ; Imberti, Cinzia ; Huang, Huaiyi ; Hands-Portman, Ian ; Sadler, Peter J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-27efff7461acdde0644d6900172443397b109687da7e1251578f288768ad506b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Antineoplastic Agents - chemical synthesis</topic><topic>Antineoplastic Agents - chemistry</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Biotin</topic><topic>Biotinylation</topic><topic>Cell Line, Tumor</topic><topic>Cell Proliferation - drug effects</topic><topic>Decomposition reactions</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Screening Assays, Antitumor</topic><topic>Female</topic><topic>Humans</topic><topic>Molecular Structure</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Optical Imaging</topic><topic>Organoplatinum Compounds - chemical synthesis</topic><topic>Organoplatinum Compounds - chemistry</topic><topic>Organoplatinum Compounds - pharmacology</topic><topic>Ovarian Neoplasms - diagnostic imaging</topic><topic>Ovarian Neoplasms - drug therapy</topic><topic>Ovarian Neoplasms - pathology</topic><topic>Photochemical Processes</topic><topic>Photodecomposition</topic><topic>Structure-Activity Relationship</topic><topic>Titration</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shi, Huayun</creatorcontrib><creatorcontrib>Imberti, Cinzia</creatorcontrib><creatorcontrib>Huang, Huaiyi</creatorcontrib><creatorcontrib>Hands-Portman, Ian</creatorcontrib><creatorcontrib>Sadler, Peter J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Chemical communications (Cambridge, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shi, Huayun</au><au>Imberti, Cinzia</au><au>Huang, Huaiyi</au><au>Hands-Portman, Ian</au><au>Sadler, Peter J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biotinylated photoactive Pt() anticancer complexes</atitle><jtitle>Chemical communications (Cambridge, England)</jtitle><addtitle>Chem Commun (Camb)</addtitle><date>2020-02-21</date><risdate>2020</risdate><volume>56</volume><issue>15</issue><spage>232</spage><epage>2323</epage><pages>232-2323</pages><issn>1359-7345</issn><eissn>1364-548X</eissn><abstract>Novel biotinylated diazido-Pt(
iv
) complexes exhibit high visible light photocytotoxicity while being stable in the dark. Photocytotoxicity and cellular accumulation of all-
trans
-[Pt(py)
2
(N
3
)
2
(biotin)(OH)] (
2a
) were enhanced significantly when bound to avidin; irradiation induced dramatic cellular morphological changes in human ovarian cancer cells treated with
2a
.
Novel biotinylated diazido-Pt(
iv
) complexes exhibit high visible light photocytotoxicity while being stable in the dark.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>31990000</pmid><doi>10.1039/c9cc07845b</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0002-8895-2342</orcidid><orcidid>https://orcid.org/0000-0003-1187-7951</orcidid><orcidid>https://orcid.org/0000-0002-2091-7954</orcidid><orcidid>https://orcid.org/0000-0001-9160-1941</orcidid><orcidid>https://orcid.org/0000-0003-2334-7886</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Chemical communications (Cambridge, England), 2020-02, Vol.56 (15), p.232-2323 |
| issn | 1359-7345 1364-548X |
| language | eng |
| recordid | cdi_pubmed_primary_31990000 |
| source | Royal Society of Chemistry:Jisc Collections:Royal Society of Chemistry Read and Publish 2022-2024 (reading list) |
| subjects | Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Biotin Biotinylation Cell Line, Tumor Cell Proliferation - drug effects Decomposition reactions Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Female Humans Molecular Structure NMR Nuclear magnetic resonance Optical Imaging Organoplatinum Compounds - chemical synthesis Organoplatinum Compounds - chemistry Organoplatinum Compounds - pharmacology Ovarian Neoplasms - diagnostic imaging Ovarian Neoplasms - drug therapy Ovarian Neoplasms - pathology Photochemical Processes Photodecomposition Structure-Activity Relationship Titration |
| title | Biotinylated photoactive Pt() anticancer complexes |
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