Correlation Between E6 and E7 Oncogenes and Malignant Transformation of Laryngeal Papillomatosis (LP) with Human Papillomavirus (HPV) in Pediatric Population

Laryngeal papillomatosis (LP) is the most common benign neoplasm affecting the upper respiratory tract mucosa in children. The most common genotypes of HPV associated with LP are types 6 and 11. Methods: Among 187 patients identified in our institution with LP, four cases showed malignant transforma...

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Bibliographic Details
Published in:Fetal and pediatric pathology 2021-08, Vol.40 (4), p.290-294
Main Authors: Khreefa, Zaid, Isaac, Vivian, Poulik, Janet, Felix, Richard, Selwanes, Wasim, Mangal, Ruchi, Dereje, Pheven, Fatouh, Khairya A., Shehata, Bahig M.
Format: Article
Language:English
Subjects:
Alphapapillomavirus - genetics
Child
Humans
Laryngeal Neoplasms
laryngeal papillomatosis
low-risk HPV
malignant transformation
oncogene E6
Oncogene Proteins, Viral - genetics
Oncogenes - genetics
Papilloma
Papillomaviridae - genetics
Papillomavirus E7 Proteins - genetics
Papillomavirus Infections - complications
Papillomavirus Infections - genetics
pediatrics
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Summary:Laryngeal papillomatosis (LP) is the most common benign neoplasm affecting the upper respiratory tract mucosa in children. The most common genotypes of HPV associated with LP are types 6 and 11. Methods: Among 187 patients identified in our institution with LP, four cases showed malignant transformation to invasive squamous carcinoma. Results: These patients had tumors with HPV viruses that showed high expression of oncogene E6 and E7 and low expression of E2. Conclusion: Malignant transformation of LP is associated with oncogenic expression of E6 and E7.
ISSN:1551-3815
1551-3823
DOI:10.1080/15513815.2019.1707921