AGO2 and its partners: a silencing complex, a chromatin modulator, and new features

AGO2 is the only member with catalytic activity in Argonaute family and contains four functional core domains, which are N domain, PAZ domain, MID domain, and PIWI domain from N-terminal to C-terminal. In traditional view, AGO2 serves as the catalytic engine of the RNA induced silencing complex and...

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Bibliographic Details
Published in:Critical reviews in biochemistry and molecular biology 2020-01, Vol.55 (1), p.33-53
Main Authors: Li, Xiaojing, Wang, Xueying, Cheng, Zeneng, Zhu, Qubo
Format: Article
Language:English
Subjects:
AGO2
Animals
Argonaute Proteins - genetics
Argonaute Proteins - metabolism
cellular processes
Chromatin - genetics
Chromatin - metabolism
Chromatin Assembly and Disassembly
DNA Breaks, Double-Stranded
DNA Repair
epigenetics
Gene Silencing
Humans
non-coding RNA
Peptide Chain Initiation, Translational
Polyadenylation
RNA Stability
RNA, Messenger - biosynthesis
RNA, Messenger - genetics
signal transduction
Transcription, Genetic
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Summary:AGO2 is the only member with catalytic activity in Argonaute family and contains four functional core domains, which are N domain, PAZ domain, MID domain, and PIWI domain from N-terminal to C-terminal. In traditional view, AGO2 serves as the catalytic engine of the RNA induced silencing complex and plays an important role in small RNAs guided post transcriptional gene silencing, including mRNA degradation and translational repression. Moreover, AGO2 also plays multiple roles in gene regulation processes in nuclei, such as chromatin remodeling, transcriptional repression and activation, double-strand break repair and alternative splicing. Recent studies have also implicated AGO2 in several other cellular processes, including alternative polyadenylation, translational activation, and transposon repression.
ISSN:1040-9238
1549-7798
DOI:10.1080/10409238.2020.1738331