Research progress in the application of in situ hydrogel system in tumor treatment

The in situ hydrogel drug delivery system is a hot research topic in recent years. Combining both properties of hydrogel and solution, in situ hydrogels can provide many advantages for drug delivery application, including easy application, high local drug concentration, prolonged drug retention time...

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Bibliographic Details
Published in:Drug delivery 2020-01, Vol.27 (1), p.460-468
Main Authors: Wei, Weipeng, Li, Hongfang, Yin, Chengchen, Tang, Fushan
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - pharmacokinetics
Bioavailability
Biocompatibility
Chemotherapy
drug delivery system
Drug Delivery Systems
Drug dosages
Humans
Hydrogels
Hydrogen bonds
In situ hydrogel
Laboratories
Medication Adherence
Neoplasms - drug therapy
Pharmacy
Phase transitions
progress
Review
tumor treatment
Tumors
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Summary:The in situ hydrogel drug delivery system is a hot research topic in recent years. Combining both properties of hydrogel and solution, in situ hydrogels can provide many advantages for drug delivery application, including easy application, high local drug concentration, prolonged drug retention time, reduced drug dose in vivo, good biocompatibility and improved patient compliance, thus has potential in tumor treatment. In this paper, the related literature reports in recent years were reviewed to summarize and discuss the research progress and development prospects in the application of in situ hydrogels in tumor treatment.
ISSN:1071-7544
1521-0464
DOI:10.1080/10717544.2020.1739171