Association of Copeptin, a Surrogate Marker of Arginine Vasopressin, with Decreased Kidney Function in Sugarcane Workers in Guatemala

Background: Vasopressin is elevated in response to heat and dehydration and has been postulated to have a role in the chronic kidney disease of unknown origin being observed in Central America. The aims of this study were to examine whether the vasopressin pathway, as measured by copeptin, is associ...

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Bibliographic Details
Published in:Annals of nutrition and metabolism 2020-01, Vol.76 (1), p.30-36
Main Authors: Butler-Dawson, Jaime, Dally, Miranda, Johnson, Richard J., Johnson, Evan C., Krisher, Lyndsay, Sánchez-Lozada, Laura-Gabriela, Griffin, Benjamin R., Brindley, Stephen, Newman, Lee S.
Format: Article
Language:English
Subjects:
Agricultural laborers
Argipressin
Basic/Transitional Science: Research Article
Biomarkers
Creatinine
Dehydration
Dehydration (Physiology)
Demographic aspects
Epidermal growth factor receptors
Fluid intake
Glomerular filtration rate
Health aspects
High temperature
Hormones
Hydration
Kidney diseases
Kidneys
Longitudinal studies
Measurement
Occupational exposure
Physiological aspects
Renal function
Risk factors
Sugarcane
Vasopressin
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Summary:Background: Vasopressin is elevated in response to heat and dehydration and has been postulated to have a role in the chronic kidney disease of unknown origin being observed in Central America. The aims of this study were to examine whether the vasopressin pathway, as measured by copeptin, is associated with the presence of kidney dysfunction, and to examine whether higher fluid intake is associated with lower circulating copeptin and thereby preserves kidney health among sugarcane workers exposed to hot conditions. Methods: Utilizing a longitudinal study of 105 workers in Guatemala, we examined relationships between hydration indices, plasma copeptin concentrations, and kidney function markers at 3 times during the 6-month harvest. We also examined whether baseline copeptin concentrations increased the odds of developing an estimated glomerular filtration rate (eGFR)
ISSN:0250-6807
1421-9697
DOI:10.1159/000506619