Biomimetic carbohydrate recognition

Carbohydrates are important but challenging targets for supramolecular chemists. They possess complex, irregular and variable structures, and are strongly attracted to water, their natural environment. This tutorial review describes work on synthetic receptors which bind carbohydrates through non-co...

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Bibliographic Details
Published in:Chemical Society reviews 2020-05, Vol.49 (9), p.2531-2545
Main Author: Davis, Anthony P
Format: Article
Language:English
Subjects:
Aqueous solutions
Biology
Biomimetic Materials - chemistry
Biomimetics
Carbohydrate Conformation
Carbohydrates
Carbohydrates - chemistry
Chemists
Receptors
Receptors, Artificial - chemistry
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Summary:Carbohydrates are important but challenging targets for supramolecular chemists. They possess complex, irregular and variable structures, and are strongly attracted to water, their natural environment. This tutorial review describes work on synthetic receptors which bind carbohydrates through non-covalent interactions, mimicking the strategies used in biology. Emphasis is placed on systems which operate in purely aqueous solution, without involvement of organic solvents. Although the problem is difficult, the careful design of complementary cavities can lead to surprisingly good results. In particular, a receptor for glucose has achieved performance which generally matches biology, and augurs well for real-world applications. Binding saccharides with non-covalent interactions is challenging, especially in the natural medium of water, but synthetic carbohydrate receptors can be surprisingly effective.
ISSN:0306-0012
1460-4744
DOI:10.1039/c9cs00391f