Consuming a ketogenic diet leads to altered hypoglycemiccounter-regulation in mice

Ketogenic diets (KDs) are becoming increasingly popular for the treatment of diabetes, yet they are associated with increased frequency of hypoglycemia. Here we report that mice fed a KD display blunted glucagon release to hypoglycemia and neuroglucopenia, suggesting that consuming a KD may increase...

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Bibliographic Details
Published in:Journal of diabetes and its complications 2020-05, Vol.34 (5), p.107557
Main Authors: Morrison, Christopher D, Hill, Cristal M, DuVall, Marina A, Coulter, Carolyn E, Gosey, Jasmin L, Herrera, Matthew J, Maisano, Lauren E, Sikaffy, Hunter X, McDougal, David H
Format: Article
Language:English
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Summary:Ketogenic diets (KDs) are becoming increasingly popular for the treatment of diabetes, yet they are associated with increased frequency of hypoglycemia. Here we report that mice fed a KD display blunted glucagon release to hypoglycemia and neuroglucopenia, suggesting that consuming a KD may increase the risk for iatrogenic hypoglycemia.
ISSN:1873-460X
DOI:10.1016/j.jdiacomp.2020.107557