Absence of FGFR3-TACC3 rearrangement in hematological malignancies with numerical chromosomal alteration

FGFR-TACC, found in different tumor types, is characterized by the fusion of a member of fibroblast grown factor receptor (FGFR) tyrosine kinase (TK) family to a member of the transforming acidic coiled-coil (TACC) proteins. Because chromosome numerical alterations, hallmarks of FGFR-TACC fusions ar...

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Published in:Hematology/oncology and stem cell therapy 2020-03
Main Authors: Banella, C, Ginevrino, M, Catalano, G, Fabiani, E, Falconi, G, Divona, M, Curzi, P, Panetta, P, Voso, M T, Noguera, N I
Format: Article
Language:English
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Summary:FGFR-TACC, found in different tumor types, is characterized by the fusion of a member of fibroblast grown factor receptor (FGFR) tyrosine kinase (TK) family to a member of the transforming acidic coiled-coil (TACC) proteins. Because chromosome numerical alterations, hallmarks of FGFR-TACC fusions are present in many hematological disorders and there are no data on the prevalence, we studied a series of patients with acute myeloid leukemia and myelodysplastic syndrome who presented numerical alterations using cytogenetic traditional analysis. None of the analyzed samples showed FGFR3-TACC3 gene fusion, so screening for this mutation at diagnosis is not recommended.
ISSN:1658-3876