Sporormielones A-E, bioactive novel C-C coupled orsellinic acid derivative dimers, and their biosynthetic origin

Sporormielones A-E ( 1-5 ), novel C-C coupled orsellinic acid derivative dimers containing tricyclic cores with a dimethylcyclopentenone unit, were obtained, of which 1-3 and 5 showed obvious short-term memory improvement activity in AD flies. Based on transcriptome analysis, 13 C labelling, and gen...

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Published in:Chemical communications (Cambridge, England) England), 2020-04, Vol.56 (33), p.467-461
Main Authors: Chen, Guo-Dong, Hu, Dan, Huang, Mei-Juan, Tang, Jia, Wang, Xiao-Xia, Zou, Jian, Xie, Jun, Zhang, Wei-Guang, Guo, Liang-Dong, Yao, Xin-Sheng, Abe, Ikuro, Gao, Hao
Format: Article
Language:English
Subjects:
Abbreviations
Alzheimer Disease
Animals
Ascomycota - metabolism
Crystallography
Dimerization
Dimers
Diptera
Gene Expression Profiling
Memory, Short-Term - drug effects
Neuroprotective Agents - chemistry
Neuroprotective Agents - metabolism
Neuroprotective Agents - pharmacology
NMR
Nuclear magnetic resonance
Quantum chemistry
Resorcinols - chemistry
Resorcinols - metabolism
Resorcinols - pharmacology
Short term
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Summary:Sporormielones A-E ( 1-5 ), novel C-C coupled orsellinic acid derivative dimers containing tricyclic cores with a dimethylcyclopentenone unit, were obtained, of which 1-3 and 5 showed obvious short-term memory improvement activity in AD flies. Based on transcriptome analysis, 13 C labelling, and gene deletion, their plausible biosynthetic mechanism was proposed. Sporormielones A-E, novel C-C coupled orsellinic acid derivative dimers containing tricyclic cores with a dimethylcyclopentenone unit, were isolated from Sporormiella sp., and their plausible biosynthetic mechanism was proposed.
ISSN:1359-7345
1364-548X
DOI:10.1039/d0cc00855a