Synergistic anti-inflammatory activities of a new flavone and other flavonoids from Tephrosia hildebrandtii vatke

A new flavone, named hildeflavone (1) along with 7 other known flavonoids were isolated from the aerial parts of Tephrosia hildebrandtii Vatke. Their characterisation was based on NMR and MS data analysis. The anti-inflammatory properties of the crude extract, isolated compounds and combination of t...

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Bibliographic Details
Published in:Natural product research 2021-11, Vol.35 (22), p.4486-4493
Main Authors: Owor, Richard Oriko, Bedane, Kibrom Gebreheiwot, Openda, Yolande Ikala, Zühlke, Sebastian, Derese, Solomon, Ong'amo, George, Ndakala, Albert, Spiteller, Michael
Format: Article
Language:English
Subjects:
anti-inflammatory
Anti-Inflammatory Agents - pharmacology
cytokine
Cytokines
Fabaceae
Flavones - pharmacology
flavonoid
Flavonoids - pharmacology
hildeflavone
Humans
Leukocytes, Mononuclear
synergy
Tephrosia
Tephrosia hildebrandtii
Tumor Necrosis Factor-alpha
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Summary:A new flavone, named hildeflavone (1) along with 7 other known flavonoids were isolated from the aerial parts of Tephrosia hildebrandtii Vatke. Their characterisation was based on NMR and MS data analysis. The anti-inflammatory properties of the crude extract, isolated compounds and combination of the compounds were investigated in lipopolysaccharide (LPS)-stimulated peripheral blood mononuclear cells (PBMCs). Treatment of the LPS-stimulated PBMCs with the isolated flavonoids at a concentration of 100 µM significantly reduced the production of interleukins (IL-1β, IL-2 and IL-6), interferon-gamma (IFN-γ), granulocyte macrophage-colony stimulating factor (GM-CSF) and tumour necrosis factor-alpha (TNF-α). It was also found that the combination of a flavone and flavanones exhibited remarkable synergistic anti-inflammatory effects on the production of the cytokines.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2020.1736065