Renal iodine 123 -metaiodobenzylguanidine scintigraphy relates to muscle sympathetic nervous activity in heart failure with reduced ejection fraction

Renal denervation is effective for modulating augmented sympathetic nerve activity (SNA) in heart failure with reduced ejection fraction (HFrEF). We have demonstrated that renal iodine -metaiodobenzylguanidine ( I-MIBG) scintigraphy is associated with muscle sympathetic nerve activity (MSNA) in pati...

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Published in:Autonomic neuroscience 2020-07, Vol.226, p.102671
Main Authors: Okabe, Yoshitaka, Murai, Hisayoshi, Tokuhisa, Hideki, Hamaoka, Takuto, Mukai, Yusuke, Sugimoto, Hiroyuki, Takashima, Shin-Ichiro, Kato, Takeshi, Matsuo, Shinro, Usui, Soichiro, Furusho, Hiroshi, Takamura, Masayuki, Kaneko, Shuichi
Format: Article
Language:English
Subjects:
3-Iodobenzylguanidine
Aged
Echocardiography
Female
Heart Failure - diagnostic imaging
Heart Failure - physiopathology
Humans
Iodine Radioisotopes
Kidney - diagnostic imaging
Male
Middle Aged
Muscles - physiopathology
Radionuclide Imaging
Radiopharmaceuticals
Sympathetic Nervous System - physiopathology
Ventricular Function, Left - physiology
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Summary:Renal denervation is effective for modulating augmented sympathetic nerve activity (SNA) in heart failure with reduced ejection fraction (HFrEF). We have demonstrated that renal iodine -metaiodobenzylguanidine ( I-MIBG) scintigraphy is associated with muscle sympathetic nerve activity (MSNA) in patients with hypertension. However, it is unclear whether renal I-MIBG scintigraphy is useful for assessment of SNA in HFrEF. The study population consisted of 24 HFrEF patients and 11 healthy subjects as controls. Patients with HFrEF underwent I-MIBG scintigraphy and hemodynamics using a Swan-Ganz catheter (SGC). HFrEF was defined as echocardiography with left ventricular ejection fraction (LVEF) 
ISSN:1872-7484
DOI:10.1016/j.autneu.2020.102671