hbsag levels can be used to rule out cirrhosis in hbeag positive chronic hepatitis b: results from the sonic-b study

Serum HBsAg levels correlate with the duration of chronic HBV infection and may predict the extent of hepatic fibrosis. We analysed data from the SONIC-B database, which contains data from 8 global randomized trials and two large hepatology centers. Relationship between HBsAg levels and presence of...

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Bibliographic Details
Published in:The Journal of infectious diseases 2020-04
Main Authors: Sonneveld, Milan J, Hansen, Bettina E, Brouwer, Willem P, Chan, Henry L-Y, Piratvisuth, Teerha, Jia, Ji-Dong, Zeuzem, Stefan, Chien, R N, de Knegt, R J, Wat, Cynthia, Pavlovic, Vedran, Gaggar, Anuj, Xie, Qing, Buti, Maria, de Man, R A, Janssen, Harry L A
Format: Article
Language:English
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Summary:Serum HBsAg levels correlate with the duration of chronic HBV infection and may predict the extent of hepatic fibrosis. We analysed data from the SONIC-B database, which contains data from 8 global randomized trials and two large hepatology centers. Relationship between HBsAg levels and presence of significant fibrosis (Ishak 3-4) or cirrhosis (Ishak 5-6) were explored and clinically relevant cut-offs were identified to rule out cirrhosis. The dataset included 2779 patients; 1866 HBeAg-positive; 322 with cirrhosis. Among HBeAg-positive patients, lower HBsAg levels were associated with higher rates of significant fibrosis (Odds Ratio [OR] 0.419, P
ISSN:1537-6613
DOI:10.1093/infdis/jiaa192