Recent advances in understanding the mechanisms of PM 2.5 -mediated neurodegenerative diseases

PM particles are widely believed to be associated with respiratory and cardiovascular diseases. However, recent studies have reported that PM may be associated with neurodegenerative diseases. The exact mechanism by which PM mediates neurotoxicity and cognitive dysfunction is still unclear. In the c...

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Published in:Toxicology letters 2020-09, Vol.329, p.31
Main Authors: Zhu, Xiaozheng, Ji, Xintong, Shou, Yikai, Huang, Yilu, Hu, Yu, Wang, Huanhuan
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Ji, Xintong
Shou, Yikai
Huang, Yilu
Hu, Yu
Wang, Huanhuan
description PM particles are widely believed to be associated with respiratory and cardiovascular diseases. However, recent studies have reported that PM may be associated with neurodegenerative diseases. The exact mechanism by which PM mediates neurotoxicity and cognitive dysfunction is still unclear. In the current work, we collected evidence supporting the association between PM exposure and development of neurodegenerative disorders. Evidence from epidemiological investigations, animal experiments, and ex vivo cell experiments showed that PM exposure may lead to neuroinflammation, oxidative stress, mitochondrial dysfunction, neuronal apoptosis, synaptic damage and ultimately neurodegenerative diseases.
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title Recent advances in understanding the mechanisms of PM 2.5 -mediated neurodegenerative diseases
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