Açaí (Euterpe oleracea Martius) Promotes Jejunal Tissue Regeneration by Enhancing Antioxidant Response in 5-Fluorouracil-Induced Mucositis

Intestinal mucositis (IM) caused by antineoplastic chemotherapy is characterized by an important inflammatory process, which may compromise ongoing treatment. Our study aimed to investigate the effect of Açaí (Euterpe oleracea Martius) on the antioxidant response in BALB/c mice pretreated with Açaí...

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Bibliographic Details
Published in:Nutrition and cancer 2021, Vol.73 (3), p.523-533
Main Authors: Magalhães, Talita Alves Faria Martins, Souza, Melina Oliveira de, Gomes, Sttefany Viana, Mendes e Silva, Raiana, Martins, Flaviano dos Santos, Freitas, Renata Nascimento de, Amaral, Joana Ferreira do
Format: Article
Language:English
Subjects:
5-Fluorouracil
Antioxidants
Catalase
Chemotherapy
Enzymatic activity
Euterpe oleracea
Histology
Inflammation
Intestine
Jejunum
Mucositis
Oxidative stress
Regeneration
Stability
Sulfhydryl groups
Superoxide dismutase
Tissue engineering
Tissues
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Summary:Intestinal mucositis (IM) caused by antineoplastic chemotherapy is characterized by an important inflammatory process, which may compromise ongoing treatment. Our study aimed to investigate the effect of Açaí (Euterpe oleracea Martius) on the antioxidant response in BALB/c mice pretreated with Açaí pulp (200 g/kg) for 14 day. A group of animals receiving a single intraperitoneal injection of 5-FU (200 mg/kg) were euthanized on day three (D3) or seven (D7) after administration, the distal jejunum was isolated for the analyses of histology, superoxide dismutase (SOD) and catalase (CAT) enzyme activities, and concentration of total sulfhydryl groups (GSH). Seven days after induction, the intake of Açaí by the IM group almost completely regenerated tissue histology. Notably, SOD activity decreased in the MUC + Açaí group (D3). CAT activity reduced on D3 and D7 in the IM groups and Açaí treatment groups, respectively. No change was observed in the total GSH concentration at the tissue level. Our results demonstrated the protective effect of Açaí pulp components on intestinal damage induced by 5-FU, as well as the ability to control the response to oxidative stress, in order to mobilize defense pathways and promote tissue repair.
ISSN:0163-5581
1532-7914
DOI:10.1080/01635581.2020.1759659