The effect of 50% oxygen on PtCO 2 in patients with stable COPD, bronchiectasis, and neuromuscular disease or kyphoscoliosis: randomised cross-over trials

High-concentration oxygen therapy causes increased arterial partial pressure of carbon dioxide (PaCO ) in patients with COPD, asthma, pneumonia, obesity and acute lung injury. The objective of these studies was to investigate whether this physiological response to oxygen therapy occurs in stable pat...

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Bibliographic Details
Published in:BMC pulmonary medicine 2020-05, Vol.20 (1), p.125
Main Authors: Pilcher, Janine, Thayabaran, Darmiga, Ebmeier, Stefan, Williams, Mathew, Back, Geraldine, Collie, Hamish, Richards, Michael, Bibby, Susan, Semprini, Ruth, Weatherall, Mark, Beasley, Richard
Format: Article
Language:English
Subjects:
Adult
Aged
Australia
Blood Gas Monitoring, Transcutaneous
Bronchiectasis - complications
Bronchiectasis - therapy
Carbon Dioxide - blood
Cross-Over Studies
Double-Blind Method
Female
Humans
Hypercapnia - etiology
Hypercapnia - physiopathology
Linear Models
Male
Middle Aged
Neuromuscular Diseases - complications
Neuromuscular Diseases - therapy
Oxygen Inhalation Therapy - methods
Partial Pressure
Pulmonary Disease, Chronic Obstructive - complications
Pulmonary Disease, Chronic Obstructive - therapy
Respiratory Rate
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Summary:High-concentration oxygen therapy causes increased arterial partial pressure of carbon dioxide (PaCO ) in patients with COPD, asthma, pneumonia, obesity and acute lung injury. The objective of these studies was to investigate whether this physiological response to oxygen therapy occurs in stable patients with neuromuscular disease or kyphoscoliosis, and bronchiectasis. Three randomised cross-over trials recruited stable patients with neuromuscular disease or kyphoscoliosis (n = 20), bronchiectasis (n = 24), and COPD (n = 24). Participants were randomised to receive 50% oxygen and 21% oxygen (air), each for 30 min, in randomly assigned order. The primary outcome was transcutaneous partial pressure of carbon dioxide (PtCO ) at 30 min. The primary analysis was a mixed linear model. Sixty six of the 68 participants had baseline PtCO values
ISSN:1471-2466