Phenylboronic ester-modified anionic micelles for ROS-stimuli response in HeLa cell

Smart polymers as ideal drug nanocarriers have attracted much attention due to the effective drug delivery, internalization and release once triggered by intracellular stimuli, as well as reduced cytotoxicity. We here reported the anionic micelle consisting of copolymer (PEG-b-PAsp) and a PBE (Pheny...

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Bibliographic Details
Published in:Drug delivery 2020-01, Vol.27 (1), p.681-690
Main Authors: Wang, Qi Y., Xu, Yi S., Zhang, Nan X., Dong, Zhi P., Zhao, Bo N., Liu, Lin C., Lu, Tao, Wang, Yue
Format: Article
Language:English
Subjects:
A549 Cells
Acids
Animals
Anionic micelles
Anions
Antibiotics, Antineoplastic - administration & dosage
Antibiotics, Antineoplastic - chemistry
Antibiotics, Antineoplastic - pharmacokinetics
Antibiotics, Antineoplastic - pharmacology
Biocompatible Materials - chemistry
Boronic Acids - chemistry
Cancer therapies
Cell Survival - drug effects
Copolymers
Cytotoxicity
Doxorubicin - administration & dosage
Doxorubicin - chemistry
Doxorubicin - pharmacokinetics
Doxorubicin - pharmacology
Drug Carriers - chemistry
drug delivery system
Drug delivery systems
Drug Liberation
HeLa Cells
Humans
Laboratories
MCF-7 Cells
Mice
Micelles
Molecular Structure
Polyethylene glycol
Polyethylene Glycols - chemistry
Reactive Oxygen Species - metabolism
ROS-Stimuli response
Spectrum analysis
Xenograft Model Antitumor Assays
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Summary:Smart polymers as ideal drug nanocarriers have attracted much attention due to the effective drug delivery, internalization and release once triggered by intracellular stimuli, as well as reduced cytotoxicity. We here reported the anionic micelle consisting of copolymer (PEG-b-PAsp) and a PBE (Phenylboronic Ester) group grafted, which can achieve fast response to intracellular ROS and enhanced anti-tumor activity. With this, PEG-b-PAsp-g-PBE/DOX system showed better tumor growth inhibition when studied on HeLa cell lines with high level of intracellular ROS and its subcutaneous tumor models. Additionally, the administration of PEG-b-PAsp-g-PBE/DOX did cause significantly lower systemic toxicity in comparison with free DOX. Hence, PEG-b-PAsp-g-PBE could be a highly efficient and safe nanocarrier to improve the efficacy of chemotherapeutic.
ISSN:1071-7544
1521-0464
DOI:10.1080/10717544.2020.1748761