Association of vitamin D 2 and D 3 with type 2 diabetes complications

• Published in: BMC endocrine disorders 2020-05, Vol.20 (1), p.65
• Main Authors: Ahmed, Lina H M, Butler, Alexandra E, Dargham, Soha R, Latif, Aishah, Robay, Amal, Chidiac, Omar M, Jayyousi, Amin, Al Suwaidi, Jassim, Crystal, Ronald G, Atkin, Stephen L, Abi Khalil, Charbel
• Format: Article
• Language: English
• Subjects: Adult; Aged; Blood Glucose - drug effects; Blood Glucose - metabolism; Cholecalciferol - blood; Cohort Studies; Cross-Sectional Studies; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - epidemiology; Dietary Supplements; Ergocalciferols - administration & dosage; Ergocalciferols - blood; Female; Humans; Male; Middle Aged; Qatar - epidemiology; Vitamin D Deficiency - blood; Vitamin D Deficiency - drug therapy; Vitamin D Deficiency - epidemiology
• ISSN: 1472-6823

Vitamin D measurement is a composite of vitamin D (25(OH)D ) and D (25(OH)D ) levels, and its deficiency is associated with the development of type 2 diabetes (T2DM) and diabetic complications; vitamin D deficiency may be treated with vitamin D supplements. This study was undertaken to determine if vitamin D and D levels differed between those with and without T2DM in this Middle Eastern population, and the relationship between diabetic microvascular complications and vitamin D and vitamin D levels in subjects with T2DM METHODS: Four hundred ninety-six Qatari subjects, 274 with and 222 without T2DM participated in the study. Plasma levels of total vitamin D and D were measured by LC-MS/MS analysis. All subjects were taking vitamin D and none were taking D supplements. Vitamin D levels were higher in diabetics, particularly in females, and higher levels were associated with hypertension and dyslipidemia in the diabetic subjects (p