The effect of cardiorespiratory fitness and physical activity levels on cognitive functions in survivors of childhood acute lymphoblastic leukemia

Introduction. Most childhood acute lymphoblastic leukemia (ALL) survivors develop chronic treatment-related adverse effects several years after the end of the treatment. Regular physical activity and a good cardiorespiratory fitness can decrease the risks of neurological disturbances and increase co...

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Published in:Pediatric hematology and oncology 2020-10, Vol.37 (7), p.582-598
Main Authors: Gendron, Élisabelle, Caru, Maxime, Léveillé, Pauline, Sultan, Serge, Robaey, Philippe, Lemay, Valérie, Drouin, Simon, Bertout, Laurence, Andelfinger, Gregor, Krajinovic, Maja, Laverdière, Caroline, Sinnett, Daniel, Lippé, Sarah, Curnier, Daniel
Format: Article
Language:English
Subjects:
Acute lymphoblastic leukemia
Adolescent
Adult
Cancer Survivors
Cardiorespiratory Fitness
Child
Cognition
cognitive function
Exercise
Female
Humans
Male
Neuropsychological Tests
Odds Ratio
physical activity
Precursor Cell Lymphoblastic Leukemia-Lymphoma - epidemiology
Precursor Cell Lymphoblastic Leukemia-Lymphoma - physiopathology
preventive fraction
Surveys and Questionnaires
Young Adult
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container_title Pediatric hematology and oncology
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creator Gendron, Élisabelle
Caru, Maxime
Léveillé, Pauline
Sultan, Serge
Robaey, Philippe
Lemay, Valérie
Drouin, Simon
Bertout, Laurence
Andelfinger, Gregor
Krajinovic, Maja
Laverdière, Caroline
Sinnett, Daniel
Lippé, Sarah
Curnier, Daniel
description Introduction. Most childhood acute lymphoblastic leukemia (ALL) survivors develop chronic treatment-related adverse effects several years after the end of the treatment. Regular physical activity and a good cardiorespiratory fitness can decrease the risks of neurological disturbances and increase cognitive function scores. The aim of this study was to examine the effect of good cardiorespiratory fitness and physical activity levels on cognitive functions. Methods. We enrolled 219 survivors of childhood ALL. The participants underwent a cardiopulmonary exercise test, neuropsychological tests of executive functions (i.e. verbal fluency, cognitive flexibility, working memory, processing speed) and completed a physical activity questionnaire. We calculated the odds ratio to obtain the preventive fraction of physical activity and cardiorespiratory fitness levels on cognitive functions. Results. The cohort is 52% male and 48% female. A total of 182 survivors (83%) have a cardiorespiratory fitness below their predicted (
doi_str_mv 10.1080/08880018.2020.1767737
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Most childhood acute lymphoblastic leukemia (ALL) survivors develop chronic treatment-related adverse effects several years after the end of the treatment. Regular physical activity and a good cardiorespiratory fitness can decrease the risks of neurological disturbances and increase cognitive function scores. The aim of this study was to examine the effect of good cardiorespiratory fitness and physical activity levels on cognitive functions. Methods. We enrolled 219 survivors of childhood ALL. The participants underwent a cardiopulmonary exercise test, neuropsychological tests of executive functions (i.e. verbal fluency, cognitive flexibility, working memory, processing speed) and completed a physical activity questionnaire. We calculated the odds ratio to obtain the preventive fraction of physical activity and cardiorespiratory fitness levels on cognitive functions. Results. The cohort is 52% male and 48% female. A total of 182 survivors (83%) have a cardiorespiratory fitness below their predicted (&lt;100%). Our analyses show that there is an association between good cardiorespiratory fitness and processing speed (preventive fraction of 70% for dominant hand (p &lt; 0.01) and 65% for non-dominant hand (p &lt; 0.01)) and with cognitive flexibility identified as the category switching measure of the D-KEFS verbal fluency (preventive fraction of 61%; p &lt; 0.05). Conclusion. Good cardiorespiratory fitness and good levels of physical activity were associated to a preventive fraction for most cognitive function parameters measured. Good cardiorespiratory fitness levels were significantly associated with a lower prevalence of deficits in processing speed (i.e., dominant hand and non-dominant hand) and in cognitive flexibility (i.e., category switching) in childhood acute lymphoblastic leukemia survivors.</description><identifier>ISSN: 0888-0018</identifier><identifier>EISSN: 1521-0669</identifier><identifier>DOI: 10.1080/08880018.2020.1767737</identifier><identifier>PMID: 32510265</identifier><language>eng</language><publisher>England: Taylor &amp; Francis</publisher><subject>Acute lymphoblastic leukemia ; Adolescent ; Adult ; Cancer Survivors ; Cardiorespiratory Fitness ; Child ; Cognition ; cognitive function ; Exercise ; Female ; Humans ; Male ; Neuropsychological Tests ; Odds Ratio ; physical activity ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - epidemiology ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - physiopathology ; preventive fraction ; Surveys and Questionnaires ; Young Adult</subject><ispartof>Pediatric hematology and oncology, 2020-10, Vol.37 (7), p.582-598</ispartof><rights>2020 Taylor &amp; Francis Group, LLC 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c366t-281733244b08e106bcc328383b76e6940348cba50c1c4a2e7c6c4844d59a132e3</citedby><cites>FETCH-LOGICAL-c366t-281733244b08e106bcc328383b76e6940348cba50c1c4a2e7c6c4844d59a132e3</cites><orcidid>0000-0003-2904-9185 ; 0000-0001-9717-192X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32510265$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gendron, Élisabelle</creatorcontrib><creatorcontrib>Caru, Maxime</creatorcontrib><creatorcontrib>Léveillé, Pauline</creatorcontrib><creatorcontrib>Sultan, Serge</creatorcontrib><creatorcontrib>Robaey, Philippe</creatorcontrib><creatorcontrib>Lemay, Valérie</creatorcontrib><creatorcontrib>Drouin, Simon</creatorcontrib><creatorcontrib>Bertout, Laurence</creatorcontrib><creatorcontrib>Andelfinger, Gregor</creatorcontrib><creatorcontrib>Krajinovic, Maja</creatorcontrib><creatorcontrib>Laverdière, Caroline</creatorcontrib><creatorcontrib>Sinnett, Daniel</creatorcontrib><creatorcontrib>Lippé, Sarah</creatorcontrib><creatorcontrib>Curnier, Daniel</creatorcontrib><title>The effect of cardiorespiratory fitness and physical activity levels on cognitive functions in survivors of childhood acute lymphoblastic leukemia</title><title>Pediatric hematology and oncology</title><addtitle>Pediatr Hematol Oncol</addtitle><description>Introduction. Most childhood acute lymphoblastic leukemia (ALL) survivors develop chronic treatment-related adverse effects several years after the end of the treatment. Regular physical activity and a good cardiorespiratory fitness can decrease the risks of neurological disturbances and increase cognitive function scores. The aim of this study was to examine the effect of good cardiorespiratory fitness and physical activity levels on cognitive functions. Methods. We enrolled 219 survivors of childhood ALL. The participants underwent a cardiopulmonary exercise test, neuropsychological tests of executive functions (i.e. verbal fluency, cognitive flexibility, working memory, processing speed) and completed a physical activity questionnaire. We calculated the odds ratio to obtain the preventive fraction of physical activity and cardiorespiratory fitness levels on cognitive functions. Results. The cohort is 52% male and 48% female. A total of 182 survivors (83%) have a cardiorespiratory fitness below their predicted (&lt;100%). Our analyses show that there is an association between good cardiorespiratory fitness and processing speed (preventive fraction of 70% for dominant hand (p &lt; 0.01) and 65% for non-dominant hand (p &lt; 0.01)) and with cognitive flexibility identified as the category switching measure of the D-KEFS verbal fluency (preventive fraction of 61%; p &lt; 0.05). Conclusion. Good cardiorespiratory fitness and good levels of physical activity were associated to a preventive fraction for most cognitive function parameters measured. 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Most childhood acute lymphoblastic leukemia (ALL) survivors develop chronic treatment-related adverse effects several years after the end of the treatment. Regular physical activity and a good cardiorespiratory fitness can decrease the risks of neurological disturbances and increase cognitive function scores. The aim of this study was to examine the effect of good cardiorespiratory fitness and physical activity levels on cognitive functions. Methods. We enrolled 219 survivors of childhood ALL. The participants underwent a cardiopulmonary exercise test, neuropsychological tests of executive functions (i.e. verbal fluency, cognitive flexibility, working memory, processing speed) and completed a physical activity questionnaire. We calculated the odds ratio to obtain the preventive fraction of physical activity and cardiorespiratory fitness levels on cognitive functions. Results. The cohort is 52% male and 48% female. A total of 182 survivors (83%) have a cardiorespiratory fitness below their predicted (&lt;100%). Our analyses show that there is an association between good cardiorespiratory fitness and processing speed (preventive fraction of 70% for dominant hand (p &lt; 0.01) and 65% for non-dominant hand (p &lt; 0.01)) and with cognitive flexibility identified as the category switching measure of the D-KEFS verbal fluency (preventive fraction of 61%; p &lt; 0.05). Conclusion. Good cardiorespiratory fitness and good levels of physical activity were associated to a preventive fraction for most cognitive function parameters measured. 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source Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list)
subjects Acute lymphoblastic leukemia
Adolescent
Adult
Cancer Survivors
Cardiorespiratory Fitness
Child
Cognition
cognitive function
Exercise
Female
Humans
Male
Neuropsychological Tests
Odds Ratio
physical activity
Precursor Cell Lymphoblastic Leukemia-Lymphoma - epidemiology
Precursor Cell Lymphoblastic Leukemia-Lymphoma - physiopathology
preventive fraction
Surveys and Questionnaires
Young Adult
title The effect of cardiorespiratory fitness and physical activity levels on cognitive functions in survivors of childhood acute lymphoblastic leukemia
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