Chemical constituents from the Knema globularia fruits and their in vitro cytotoxicity

Two new compounds, designated as knecorticosanones A-B (1-2), along with three known compounds (3-5) were isolated from the fruits of Knema globularia. Their structures were elucidated by extensive spectroscopy analysis, including 1D- and 2D-NMR, UV, IR, and HRESIMS and by comparison with the report...

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Published in:Natural product research 2022-01, Vol.36 (1), p.256-262
Main Authors: Pham, Ty Viet, Bach, Hieu Kim Thi, Ho, Duc Viet, Nguyen, Bao Chi
Format: Article
Language:English
Subjects:
Antineoplastic Agents, Phytogenic - pharmacology
Cell Line, Tumor
cytotoxicity
Fruit
knecorticosanones A-B
Knema globularia
malabaricone D
Molecular Structure
Myristicaceae
Plantaginaceae
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creator Pham, Ty Viet
Bach, Hieu Kim Thi
Ho, Duc Viet
Nguyen, Bao Chi
description Two new compounds, designated as knecorticosanones A-B (1-2), along with three known compounds (3-5) were isolated from the fruits of Knema globularia. Their structures were elucidated by extensive spectroscopy analysis, including 1D- and 2D-NMR, UV, IR, and HRESIMS and by comparison with the reported data in the literature. Compounds 1-5 were evaluated for their cytotoxicity. Knecorticosanone B (2) and malabaricone D (5) exhibited moderate cytotoxic effect against Hep-G2, MCF-7 and SK-LU-1 cell lines with IC 50 values ranging from 8.76 ± 1.02 to 18.74 ± 1.75 μM while knecorticosanone A (1), virolane (3) and 7-hydroxy-3′,4′-methylenedioxyflavan (4) exhibited weak inhibitory effect against these cell lines with IC 50 values ranging from 25.85 ± 2.75 to 66.75 ± 2.08 μM.
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subjects Antineoplastic Agents, Phytogenic - pharmacology
Cell Line, Tumor
cytotoxicity
Fruit
knecorticosanones A-B
Knema globularia
malabaricone D
Molecular Structure
Myristicaceae
Plantaginaceae
title Chemical constituents from the Knema globularia fruits and their in vitro cytotoxicity
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