Sophocarpine ameliorates cardiac hypertrophy through activation of autophagic responses

Mounting evidences indicate that autophagy is an essential homeostatic mechanism to maintain the global cardiac structure function. Sophocarpine (SOP), a major bioactive compound derived from the natural plant Sophora flavescens. However, the role of SOP in cardiac hypertrophy remain to be fully elu...

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Published in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2020-10, Vol.84 (10), p.2054-2061
Main Authors: Lin, Yue-Bao, Huang, Dong-Jian, Huang, Huan-Liang, Chen, De-Xiong, Huang, Jiong-Hua
Format: Article
Language:English
Subjects:
Alkaloids - pharmacology
angiotensin II
Angiotensin II - pharmacology
Animals
autophagy
Autophagy - drug effects
cardiac hypertrophy
Cardiomegaly - drug therapy
Cardiomegaly - pathology
Gene Expression Regulation - drug effects
Male
Mice
Mice, Inbred C57BL
Myocardium - metabolism
Myocardium - pathology
Sophocarpine
Ventricular Remodeling - drug effects
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Summary:Mounting evidences indicate that autophagy is an essential homeostatic mechanism to maintain the global cardiac structure function. Sophocarpine (SOP), a major bioactive compound derived from the natural plant Sophora flavescens. However, the role of SOP in cardiac hypertrophy remain to be fully elucidated. In the present study, we tested the hypothesis that SOP protects against Ang II-induced cardiac hypertrophy by mediating the regulation of autophagy. The results demonstrated that SOP attenuated the Ang II-induced cardiac hypertrophy, as assessed by measurements of echocardiography parameters, the ratios of heart weight/body weight and left ventricle weight/body weight, histopathological staining, cross-sectional cardiomyocyte area, and the expression levels of cardiac hypertrophic markers. The anti-hypertrophic effect of SOP was mediated by activating autophagy-related pathway, as revealed by reversal of the increased autophagy marker protein expression. These findings reveal a novel mechanism of SOP attenuating cardiac hypertrophy via activating autophagy-related signaling pathways. SOP mitigated Ang II-induced cardiac hypertrophy in mice, partly through activating autophagy-related pathway.
ISSN:0916-8451
1347-6947
DOI:10.1080/09168451.2020.1780111