Risk of bacteremia in patients with cutaneous T-cell lymphoma (CTCL)

Patients with CTCL are at increased risk for bacteremia which is a leading cause of morbidity and mortality. We assessed risk factors for and the impact of bacteremia on survival in a retrospective cohort of 188 CTCL patients at a single US academic institution treated between 1990 and 2018. With a...

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Bibliographic Details
Published in:Leukemia & lymphoma 2020-09, Vol.61 (11), p.2652-2658
Main Authors: Allen, Pamela B., Switchenko, Jeffrey, Ayers, Amy, Kim, Esther, Lechowicz, Mary Jo
Format: Article
Language:English
Subjects:
bacteremia
Bacteremia - epidemiology
Bacteremia - etiology
CTCL
Female
Humans
Lymphoma, T-Cell, Cutaneous - complications
Lymphoma, T-Cell, Cutaneous - epidemiology
Mycosis Fungoides
Retrospective Studies
sepsis
Skin Neoplasms
staphylococcus
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Summary:Patients with CTCL are at increased risk for bacteremia which is a leading cause of morbidity and mortality. We assessed risk factors for and the impact of bacteremia on survival in a retrospective cohort of 188 CTCL patients at a single US academic institution treated between 1990 and 2018. With a median follow up of 6.2 years, 20% of patients (n = 36) developed 79 bacteremia events. Risk factors for bacteremia included advanced stage, female gender, African American (AA) race, invasive lines, and chemotherapy. Bacteremia was associated with an increased risk of death on univariate and multivariable models. Bacteremia is associated with an increased risk of death in patients with CTCL. The greatest avoidable risk factors included chemotherapy treatment and presence of an invasive line. Key points 20% of patients developed bacteremia at any point in time in this analysis. Bacteremia is associated with an increased risk of death in patients with CTCL Risk factors for bacteremia include advanced stage, female gender, AA race, invasive line, and chemotherapy.
ISSN:1042-8194
1029-2403
DOI:10.1080/10428194.2020.1779259