A near-infrared light-controlled, ultrasensitive one-step photoelectrochemical detection of dual cell apoptosis indicators in living cancer cells

Here, a near-infrared (NIR) light-controlled, ultrasensitive one-step photoelectrochemical (PEC) strategy was constructed to simultaneously detect cell apoptosis indicators, phosphatidylserine (Pho) and sodium-potassium adenosine triphosphatase (Sat), on living cancer cells. Using NIR light as excit...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2020-07, Vol.56 (6), p.8488-8491
Main Authors: Zheng, Ying-Ning, Xiong, Cheng-Yi, Zhuo, Ying, Chai, Ya-Qin, Liang, Wen-Bin, Yuan, Ruo
Format: Article
Language:English
Subjects:
Adenosine
Adenosine triphosphatase
Apoptosis
Apoptosis - drug effects
Cancer
Cell Line, Tumor
Doxorubicin - pharmacology
Electrochemical analysis
Electrochemical Techniques - methods
Encryption
Humans
Indicators
Infrared Rays
Kinetics
Methylene blue
Methylene Blue - chemistry
Microscopy, Confocal
Near infrared radiation
Phosphatidylserines - analysis
Photoelectric effect
Photoelectric emission
Quantum dots
Quantum Dots - chemistry
Sodium-Potassium-Exchanging ATPase - analysis
Strategy
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Summary:Here, a near-infrared (NIR) light-controlled, ultrasensitive one-step photoelectrochemical (PEC) strategy was constructed to simultaneously detect cell apoptosis indicators, phosphatidylserine (Pho) and sodium-potassium adenosine triphosphatase (Sat), on living cancer cells. Using NIR light as excitation, the signal probe methylene blue (Tag kinetic ) could be released, leading to a gradually decreased photocurrent signal I kinetic ; meanwhile, the photocurrent I stable of the signal probe carbon quantum dots (Tag stable ) remained stable. The simultaneous detection of Pho and Sat could be achieved based on rapid one-step PEC detection under single NIR light with the assistance of a smart signal decryption strategy with I kinetic and I stable . Importantly, this proposal provides more effective drug candidates with milder pharmaceutical effect but improved safety. The proposed near-infrared (NIR) light-controlled, one-step photoelectrochemical (PEC) strategy could simultaneously detect cell apoptosis indicators, phosphatidylserine (Pho) and sodium potassium adenosine triphosphatase (Sat), on living cancer cells.
ISSN:1359-7345
1364-548X
DOI:10.1039/d0cc02996c