Troponin elevation in acute ischemic stroke-unspecific or acute myocardial infarction? : Diagnostics and clinical implications

• Published in: Herz 2021-08, Vol.46 (4), p.342
• Main Authors: Kruska, M, Fastner, C, Scheitz, J F, Kolb, A, Rutsch, M, Papavassiliu, T, Borggrefe, M, Alonso, A, Akin, I, Szabo, K, Baumann, S
• Format: Article
• Language: ger
• Subjects: Brain Ischemia; Humans; Ischemic Stroke; Myocardial Infarction; Stroke - diagnosis; Troponin
• ISSN: 1615-6692
• DOI: 10.1007/s00059-020-04967-3

Routine determination of troponin levels is recommended for all patients with acute ischemic stroke. In 20-55% of these patients the troponin levels are elevated, which may be caused by ischemic as well as non-ischemic myocardial damage and particularly neurocardiogenic myocardial damage. In patients with acute ischemic stroke, the prevalence of previously unknown coronary heart disease is reported to be up to 27% and is prognostically relevant for these patients; however, relevant coronary stenoses are less frequently detected in stroke patients with troponin elevation compared to patients with non-ST elevation myocardial infarction. The risk of secondary intracerebral hemorrhage due to the necessity for dual platelet aggregation inhibition illustrates the challenging indication for invasive coronary diagnostics and revascularization. Therefore, a diagnostic work-up and interdisciplinary risk evaluation appropriate to the urgency are necessary in order to be able to determine a reasonable treatment approach with timing of the intervention, type and duration of blood thinning. In addition to conventional examination methods, multimodal cardiac imaging is increasingly used for this purpose. This review article aims to provide a pragmatic and clinically oriented approach to diagnostic and therapeutic procedures, taking into account the available evidence.