Calbindin-D 28K , parvalbumin, and calretinin in young and aged human locus coeruleus

Certain neuronal populations, including basal forebrain cholinergic neurons (BFCN) and noradrenergic neurons of the locus coeruleus (LC), are selectively vulnerable to pathology and loss early in the course of aging and Alzheimer's disease (AD). Human BFCN show substantial loss of the calcium-b...

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Bibliographic Details
Published in:Neurobiology of aging 2020-10, Vol.94, p.243
Main Authors: Lamerand, Sydney, Shahidehpour, Ryan, Ayala, Ivan, Gefen, Tamar, Mesulam, M-Marsel, Bigio, Eileen, Geula, Changiz
Format: Article
Language:English
Subjects:
Adrenergic Neurons - metabolism
Adrenergic Neurons - pathology
Adult
Aged
Aging - metabolism
Aging - pathology
Alzheimer Disease - metabolism
Alzheimer Disease - pathology
Calbindin 1 - metabolism
Calbindin 2 - metabolism
Cholinergic Neurons - metabolism
Cholinergic Neurons - pathology
Female
Humans
Locus Coeruleus - cytology
Locus Coeruleus - metabolism
Male
Middle Aged
Neurofibrillary Tangles - metabolism
Neurofibrillary Tangles - pathology
Parvalbumins - metabolism
Young Adult
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Summary:Certain neuronal populations, including basal forebrain cholinergic neurons (BFCN) and noradrenergic neurons of the locus coeruleus (LC), are selectively vulnerable to pathology and loss early in the course of aging and Alzheimer's disease (AD). Human BFCN show substantial loss of the calcium-binding protein (CBP), calbindin-D (CB), during normal aging, which is associated with formation of neurofibrillary tangles and BFCN loss in AD. Here we determined if, similar to the BFCN, LC neurons contain CB or the other 2 ubiquitous CBPs parvalbumin and calretinin, and whether these proteins display an age-related loss from LC neurons. Immunostaining for CBP and tyrosine hydroxylase, a marker of catecholaminergic neurons, was used in sections from the LC of young and aged human brains. Parvalbumin and calretinin immunoreactivities were completely absent from human LC neurons. A subpopulation of LC neurons (~10%) contained CB immunoreactivity. Quantitative analysis revealed no age-related loss of CB from LC neurons. Thus, unlike the BFCN, age-related loss of CB does not figure prominently in the selective vulnerability of LC neurons to degeneration in AD.
ISSN:1558-1497
DOI:10.1016/j.neurobiolaging.2020.06.006