Acute effects of lactic acid-fermented and enzyme-digested soybean on protein synthesis via mTOR signaling in the skeletal muscle

Protein-containing nutrients result in the efficient hypertrophy of muscles by increasing muscle protein synthesis. Soybean is often ingested by athletes or individuals who exercise; however, it takes very long to be absorbed. Lactic acid-fermented and enzyme-digested (LFED) soybean is absorbed fast...

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Bibliographic Details
Published in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2020-11, Vol.84 (11), p.2360-2366
Main Authors: Ono, Kohei, Tanaka, Minoru, Ikeji, Takuya, Nakanishi, Ryosuke, Hirabayashi, Takumi, Tategaki, Airo, Kondo, Hiroyo, Ishihara, Akihiko, Fujino, Hidemi
Format: Article
Language:English
Subjects:
Animals
Digestion
Lactic Acid - metabolism
lactic acid-fermented and enzyme-digested soybean
Male
Mice
Mice, Inbred ICR
mTOR pathway
muscle protein synthesis
Muscle, Skeletal - anatomy & histology
Muscle, Skeletal - cytology
Muscle, Skeletal - drug effects
Organ Size - drug effects
Peptide Hydrolases - metabolism
ribosomal protein S6
Signal Transduction - drug effects
Soybean
Soybean Proteins - metabolism
Soybean Proteins - pharmacology
TOR Serine-Threonine Kinases - metabolism
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Summary:Protein-containing nutrients result in the efficient hypertrophy of muscles by increasing muscle protein synthesis. Soybean is often ingested by athletes or individuals who exercise; however, it takes very long to be absorbed. Lactic acid-fermented and enzyme-digested (LFED) soybean is absorbed faster than untreated soybean. This study aims at determining muscle protein synthesis after ingesting a single bolus of soybean or LFED soybean produced by lactic acid bacteria and protease digestion. Eight-week-old overnight-fasted ICR mice were administered powdered or LFED soybean. Mice were euthanized at 7, 15, 30, 60, 90, and 120 min after soybean intake. We have demonstrated that LFED soybean administration was quicker in stimulating muscle protein synthesis by activating mammalian target of rapamycin (mTOR) signaling than orally ingesting untreated soybean in the gastrocnemius muscle. These results suggested that LFED soybean is a more efficient source of nutrition for muscle hypertrophy than untreated soybean. Schema for acute effects of lactic acid-fermented and enzyme-digested soybean on protein synthesis via mTOR signaling in the skeletal muscle
ISSN:0916-8451
1347-6947
DOI:10.1080/09168451.2020.1795810