The iboga enigma: the chemistry and neuropharmacology of iboga alkaloids and related analogs

Covering: 2000 up to 2020 Few classes of natural products have inspired as many chemists and biologists as have the iboga alkaloids. This family of monoterpenoid indole alkaloids includes the anti-addictive compound ibogaine as well as catharanthine, a precursor to the chemotherapeutic vinblastine....

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Bibliographic Details
Published in:Natural product reports 2021-03, Vol.38 (2), p.37-329
Main Authors: Iyer, Rishab N, Favela, David, Zhang, Guoliang, Olson, David E
Format: Article
Language:English
Subjects:
Alkaloids
Alkaloids - biosynthesis
Alkaloids - chemistry
Alkaloids - isolation & purification
Alkaloids - pharmacology
Animals
Biosynthesis
Chemical synthesis
Chemists
Humans
Ibogaine
Ibogaine - analogs & derivatives
Ibogaine - chemical synthesis
Ibogaine - pharmacology
Indoles
Mental disorders
Molecular Structure
Natural products
Pharmacology
Tabernaemontana - chemistry
Vinblastine
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Summary:Covering: 2000 up to 2020 Few classes of natural products have inspired as many chemists and biologists as have the iboga alkaloids. This family of monoterpenoid indole alkaloids includes the anti-addictive compound ibogaine as well as catharanthine, a precursor to the chemotherapeutic vinblastine. Despite being known for over 120 years, these small molecules continue to challenge our assumptions about biosynthetic pathways, catalyze our creativity for constructing complex architectures, and embolden new approaches for treating mental illness. This review will cover recent advances in both the biosynthesis and chemical synthesis of iboga alkaloids as well as their use as next-generation neurotherapeutics. Whenever appropriate, we provide historical context for the discoveries of the past decade and indicate areas that have yet to be resolved. While significant progress regarding their chemistry and pharmacology has been made since the 1960s, it is clear that the iboga alkaloids will continue to stoke scientific innovation for years to come. Few classes of natural products have inspired as many chemists and biologists as have the iboga alkaloids. This review covers recent advances in the biosynthesis and chemical synthesis of iboga alkaloids and their use as neurotherapeutics.
ISSN:0265-0568
1460-4752
DOI:10.1039/d0np00033g