Strepyrazinone, a tricyclic diketopiperazine derivative with cytotoxicity from a marine-derived actinobacterium

Strepyrazinone (1), a tricyclic diketopiperazine derivative with a carbon skeleton unprecedented in natural products, was isolated from the marine-derived Streptomyces sp. B223. Its structure was elucidated by spectroscopic analyses and electronic circular dichroism calculation. Compound 1 showed cy...

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Bibliographic Details
Published in:Journal of asian natural products research 2021-10, Vol.23 (10), p.968-974
Main Authors: Zhang, Lu, Feng, Ling-Ling, Wang, Guang-Fei, Yang, Qiao-Li, Fu, Xin-Zhen, Li, Zhi, Liu, Ming, Kou, Li-Juan, Xu, Bo, Xie, Ze-Ping, Zhang, Shu-Min, Guo, Lin
Format: Article
Language:English
Subjects:
Circular dichroism
cytotoxic activity
Cytotoxicity
Dichroism
diketopiperazine derivative
Natural products
Streptomyces sp
strepyrazinone
Toxicity
Tumor cell lines
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Summary:Strepyrazinone (1), a tricyclic diketopiperazine derivative with a carbon skeleton unprecedented in natural products, was isolated from the marine-derived Streptomyces sp. B223. Its structure was elucidated by spectroscopic analyses and electronic circular dichroism calculation. Compound 1 showed cytotoxic activity against HCT-116 cancer cell lines with an IC 50 value of 0.34 µM.
ISSN:1028-6020
1477-2213
DOI:10.1080/10286020.2020.1801649