Cholinergic Synaptic Homeostasis Is Tuned by an NFAT-Mediated α7 nAChR-K v 4/Shal Coupled Regulatory System

Homeostatic synaptic plasticity (HSP) involves compensatory mechanisms employed by neurons and circuits to preserve signaling when confronted with global changes in activity that may occur during physiological and pathological conditions. Cholinergic neurons, which are especially affected in some pa...

Full description

Saved in:
Bibliographic Details
Published in:Cell reports (Cambridge) 2020-09, Vol.32 (10), p.108119
Main Authors: Eadaim, Abdunaser, Hahm, Eu-Teum, Justice, Elizabeth D, Tsunoda, Susan
Format: Article
Language:English
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Homeostatic synaptic plasticity (HSP) involves compensatory mechanisms employed by neurons and circuits to preserve signaling when confronted with global changes in activity that may occur during physiological and pathological conditions. Cholinergic neurons, which are especially affected in some pathologies, have recently been shown to exhibit HSP mediated by nicotinic acetylcholine receptors (nAChRs). In Drosophila central neurons, pharmacological blockade of activity induces a homeostatic response mediated by the Drosophila α7 (Dα7) nAChR, which is tuned by a subsequent increase in expression of the voltage-dependent K 4/Shal channel. Here, we show that an in vivo reduction of cholinergic signaling induces HSP mediated by Dα7 nAChRs, and this upregulation of Dα7 itself is sufficient to trigger transcriptional activation, mediated by nuclear factor of activated T cells (NFAT), of the K 4/Shal gene, revealing a receptor-ion channel system coupled for homeostatic tuning in cholinergic neurons.
ISSN:2211-1247