Effects of vitamin D supplementation on metabolic parameters of women with polycystic ovary syndrome: a meta-analysis of randomized controlled trials

• Published in: Gynecological endocrinology 2021-05, Vol.37 (5), p.446-455
• Main Authors: Wang, Li, Wen, Xinqiang, Lv, Shulan, Tian, Sijuan, Jiang, Yifan, Yang, Xiaofeng
• Format: Article
• Language: English
• Subjects: Blood Glucose - drug effects; Dietary Supplements; Female; Humans; Lipid Metabolism - drug effects; meta-analysis; metabolic parameters; polycystic ovary syndrome; Polycystic Ovary Syndrome - drug therapy; randomized controlled trials; Randomized Controlled Trials as Topic; Vitamin D - pharmacology; Vitamin D - therapeutic use; Vitamin D supplementation; Vitamins - pharmacology; Vitamins - therapeutic use
• ISSN: 0951-3590; 1473-0766
• DOI: 10.1080/09513590.2020.1813272

The purpose of this meta-analysis was to evaluate the effects of vitamin D supplementation on metabolic parameters of women with polycystic ovary syndrome (PCOS). We performed a literature search of databases and identified randomized controlled trials (RCTs) published prior to December 2019. A meta-analysis was conducted using RevMan 5.3 and Stata 12.0 software. We compared the effects of vitamin D supplementation alone to the administration of placebos on metabolic parameters of PCOS women with vitamin D deficiency. Ten articles of RCTs were included and analyzed in this meta-analysis, which included a total of 520 PCOS women. Our meta-analysis results showed no significant effects of vitamin D supplementation on BMI (p = .43), systolic blood pressure (p = .05), diastolic blood pressure (p = .87), fasting insulin concentration (p = .86), HOMA-IR (p = .47), HDL-C (p = .76), LDL-C (p = .23) and triglyceride (p = .77). Both low dose vitamin D supplementation (