Effects of vitamin D supplementation on metabolic parameters of women with polycystic ovary syndrome: a meta-analysis of randomized controlled trials

The purpose of this meta-analysis was to evaluate the effects of vitamin D supplementation on metabolic parameters of women with polycystic ovary syndrome (PCOS). We performed a literature search of databases and identified randomized controlled trials (RCTs) published prior to December 2019. A meta...

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Published in:Gynecological endocrinology 2021-05, Vol.37 (5), p.446-455
Main Authors: Wang, Li, Wen, Xinqiang, Lv, Shulan, Tian, Sijuan, Jiang, Yifan, Yang, Xiaofeng
Format: Article
Language:English
Subjects:
Blood Glucose - drug effects
Dietary Supplements
Female
Humans
Lipid Metabolism - drug effects
meta-analysis
metabolic parameters
polycystic ovary syndrome
Polycystic Ovary Syndrome - drug therapy
randomized controlled trials
Randomized Controlled Trials as Topic
Vitamin D - pharmacology
Vitamin D - therapeutic use
Vitamin D supplementation
Vitamins - pharmacology
Vitamins - therapeutic use
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cited_by cdi_FETCH-LOGICAL-c366t-5eff43e15d3dec6b056c7284ea21a8cc3a3fd4eb633826ce65301d6d1a48ff073
cites cdi_FETCH-LOGICAL-c366t-5eff43e15d3dec6b056c7284ea21a8cc3a3fd4eb633826ce65301d6d1a48ff073
container_end_page 455
container_issue 5
container_start_page 446
container_title Gynecological endocrinology
container_volume 37
creator Wang, Li
Wen, Xinqiang
Lv, Shulan
Tian, Sijuan
Jiang, Yifan
Yang, Xiaofeng
description The purpose of this meta-analysis was to evaluate the effects of vitamin D supplementation on metabolic parameters of women with polycystic ovary syndrome (PCOS). We performed a literature search of databases and identified randomized controlled trials (RCTs) published prior to December 2019. A meta-analysis was conducted using RevMan 5.3 and Stata 12.0 software. We compared the effects of vitamin D supplementation alone to the administration of placebos on metabolic parameters of PCOS women with vitamin D deficiency. Ten articles of RCTs were included and analyzed in this meta-analysis, which included a total of 520 PCOS women. Our meta-analysis results showed no significant effects of vitamin D supplementation on BMI (p = .43), systolic blood pressure (p = .05), diastolic blood pressure (p = .87), fasting insulin concentration (p = .86), HOMA-IR (p = .47), HDL-C (p = .76), LDL-C (p = .23) and triglyceride (p = .77). Both low dose vitamin D supplementation (
doi_str_mv 10.1080/09513590.2020.1813272
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We performed a literature search of databases and identified randomized controlled trials (RCTs) published prior to December 2019. A meta-analysis was conducted using RevMan 5.3 and Stata 12.0 software. We compared the effects of vitamin D supplementation alone to the administration of placebos on metabolic parameters of PCOS women with vitamin D deficiency. Ten articles of RCTs were included and analyzed in this meta-analysis, which included a total of 520 PCOS women. Our meta-analysis results showed no significant effects of vitamin D supplementation on BMI (p = .43), systolic blood pressure (p = .05), diastolic blood pressure (p = .87), fasting insulin concentration (p = .86), HOMA-IR (p = .47), HDL-C (p = .76), LDL-C (p = .23) and triglyceride (p = .77). Both low dose vitamin D supplementation (&lt;4000 IU/day) and high dose vitamin D supplementation (≥4000 IU/day) were found to significantly decreased the fasting glucose concentration (p = .01, p = .001, respectively). Vitamin D supplementation significantly decreased total cholesterol concentration (p = .03). 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Vitamin D supplementation significantly decreased total cholesterol concentration (p = .03). 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source Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list)
subjects Blood Glucose - drug effects
Dietary Supplements
Female
Humans
Lipid Metabolism - drug effects
meta-analysis
metabolic parameters
polycystic ovary syndrome
Polycystic Ovary Syndrome - drug therapy
randomized controlled trials
Randomized Controlled Trials as Topic
Vitamin D - pharmacology
Vitamin D - therapeutic use
Vitamin D supplementation
Vitamins - pharmacology
Vitamins - therapeutic use
title Effects of vitamin D supplementation on metabolic parameters of women with polycystic ovary syndrome: a meta-analysis of randomized controlled trials
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