ARF6 controls RHOB targeting to endosomes regulating cancer cell invasion

Endocytic trafficking has emerged as an essential mechanism to spatiotemporally coordinate signaling protein complexes that control cytoskeletal dynamics and cell motility. Our study established an unexpected regulatory mechanism whereby ADP ribosylation factors 6 (ARF6) controls the stability and e...

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Bibliographic Details
Published in:Molecular & cellular oncology 2020-09, Vol.7 (5), p.1766932-1766932
Main Authors: Zaoui, Kossay, Smith, Harvey Wilmore, Park, Morag, Duhamel, Stéphanie
Format: Article
Language:English
Subjects:
ARF6
Author's Views
Cell invasion
MET receptor tyrosine kinase
Other
RHO GTPase
RHOB
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Summary:Endocytic trafficking has emerged as an essential mechanism to spatiotemporally coordinate signaling protein complexes that control cytoskeletal dynamics and cell motility. Our study established an unexpected regulatory mechanism whereby ADP ribosylation factors 6 (ARF6) controls the stability and endosomal localization of RAS homologous protein B (RHOB) to regulate cell invasion downstream of the oncogenic receptor tyrosine kinase, MET.
ISSN:2372-3556
2372-3556
DOI:10.1080/23723556.2020.1766932