Erythrophagocytosis by blast cells and de novo T cell LAL without cytogenetic abnormalities in a Moroccan patient

Erythrophagocytosis by blast cells is due to hyperactivation of blast cells. Erythrophagocytosis is associated with T cell myeloid hemopathies (8;16). This study shows an exceptional case of erythrophagocytosis by blast cells in a patient with acute T-lymphoblastic leukemia without cytogenetic abnor...

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Bibliographic Details
Published in:The Pan African medical journal 2020, Vol.36, p.202
Main Authors: Kahouli, Sophia, Zahid, Hafid, Khorassani, Mohamed El, Kabbaj, Saâd El, Benkirane, Majid, Messaoudi, Nezha
Format: Article
Language:fre
Subjects:
Erythrocytes - cytology
Female
Fever - etiology
Humans
Morocco
Myelography
Phagocytosis - physiology
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - diagnosis
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - pathology
Prognosis
Young Adult
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Summary:Erythrophagocytosis by blast cells is due to hyperactivation of blast cells. Erythrophagocytosis is associated with T cell myeloid hemopathies (8;16). This study shows an exceptional case of erythrophagocytosis by blast cells in a patient with acute T-lymphoblastic leukemia without cytogenetic abnormalities. We here report the case of A.Z, aged 19 years presenting with febrile syndrome with dizziness and phosphenes, tumor syndrome with amygdala and gingival hypertrophy. Blood count revealed hyperleukocytosis (399.5 G/L), with aregenerative anemia (Hb: 9.3 g/dl) and thrombocytopenia (platelet count: 40 g/L). Myelogram showed 90% of blast cells (MPO-negative) with erythrophagocytosis by blast cells images. Immunophenotyping confirmed T-cell LAL. Cytogenetic analysis was normal. Erythrophagocytosis by blast cells in patients with T-cell LAL appears to be a separate entity, hence the importance of images on diagnosis, prognosis and treatment of T-cell LAL.
ISSN:1937-8688