Antileishmanial activity of the essential oils of Myrcia ovata Cambess. and Eremanthus erythropappus (DC) McLeisch leads to parasite mitochondrial damage

is a species causative of cutaneous and anergic diffuse cutaneous leishmaniasis, treatment-resistant form, in the New World. Plants essential oils exhibit great potential as microbicide agents. We described the composition of the essential oils of two plants native from Brazil, , with geranial and n...

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Bibliographic Details
Published in:Natural product research 2020-10, p.1
Main Authors: Amorim Gomes, Geovany, Martins-Cardoso, Karina, Dos Santos, Frances Regiane, Florencio, Melissa, Rosa, Dayana, Araujo Zuma, Aline, Pinheiro Santiago, Gilvandete Maria, M Motta, Maria Cristina, Carvalho, Mario Geraldo de, Fampa, Patrícia
Format: Article
Language:English
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Summary:is a species causative of cutaneous and anergic diffuse cutaneous leishmaniasis, treatment-resistant form, in the New World. Plants essential oils exhibit great potential as microbicide agents. We described the composition of the essential oils of two plants native from Brazil, , with geranial and neral as major constituents, and with α-bisabolol. effects of these essential oils on promastigotes growth and ultrastructure were analysed as well as their cytotoxicity to murine macrophages. Both oils were highly active with IC /96 h of 8.69 and 9.53 µg/mL for and against promastigotes and caused ultrastructural alterations including mitochondrial enlargement. Cytotoxicity for murine macrophages varied with the oil concentrations. The IC low values of both and oils against and their relative low cytotoxicity to mammal host cells support their potential use against cutaneous leishmaniasis.
ISSN:1478-6427