Multilevel regulation and molecular mechanism of poly (rC)‐binding protein 1 in cancer

• Published in: The FASEB journal 2020-12, Vol.34 (12), p.15647-15658
• Main Authors: Zhang, Xuetian, Di, Cuixia, Chen, Yuhong, Wang, Jing, Su, Ruowei, Huang, Guomin, Xu, Caipeng, Chen, Xiaohua, Long, Feng, Yang, Hongying, Zhang, Hong
• Format: Article
• Language: English
• Subjects: Animals; Apoptosis - genetics; Autophagy - genetics; cancer therapy; Carcinogenesis - genetics; DNA-Binding Proteins - genetics; gene expression; Gene Expression - genetics; Humans; mechanisms; Neoplasms - genetics; PCBP1; RNA-Binding Proteins - genetics; Tumor Microenvironment - genetics; tumor suppressor
• ISSN: 0892-6638; 1530-6860
• DOI: 10.1096/fj.202000911R

Poly (rC)‐binding protein 1 (PCBP1), an RNA‐ or DNA‐binding protein with a relative molecular weight of 38 kDa, which is characterized by downregulation in many cancer types. Numerous cases have indicated that PCBP1 could be considered as a tumor suppressor to inhibit tumorigenesis, development, and metastasis. In the current review, we described the multilevel regulatory roles of PCBP1, including gene transcription, alternative splicing, and translation of many cancer‐related genes. Additionally, we also provided a brief overview about the inhibitory effect of PCBP1 on most common tumors. More importantly, we summarized the current research status about PCBP1 in hypoxic microenvironment, autophagy, apoptosis, and chemotherapy of cancer cells, aiming to clarify the molecular mechanisms of PCBP1 in cancer. Taken together, in‐depth study of PCBP1 in cancer may provide new ideas for cancer therapy.