Effect of taxifolin on cisplatin-associated oxidative optic nerve damage in rats

To investigate the effect of taxifolin on cisplatin-induced oxidative and proinflammatory optic nerve damage in rats. A total of 18 albino Wistar male rats were assigned into 3 groups, as follows; Group 1: Control group, Group 2: Only cisplatin administered group for 14 days (Cisplatin group), and G...

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Published in:Cutaneous and ocular toxicology 2021-01, Vol.40 (1), p.1-6
Main Authors: Ahiskali, Ibrahim, Ferah Okkay, Irmak, Mammadov, Renad, Okkay, Ufuk, Keskin Cimen, Ferda, Kurt, Nezahat, Suleyman, Halis
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents, Non-Steroidal - administration & dosage
cisplatin
Cisplatin - adverse effects
Disease Models, Animal
Male
Optic Nerve - drug effects
Optic Nerve - pathology
Optic Nerve Diseases - chemically induced
Optic Nerve Diseases - drug therapy
optic nerve toxicity
Oxidative Stress - drug effects
Oxidative Stress - immunology
Quercetin - administration & dosage
Quercetin - analogs & derivatives
rat
Rats
Taxifolin
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Summary:To investigate the effect of taxifolin on cisplatin-induced oxidative and proinflammatory optic nerve damage in rats. A total of 18 albino Wistar male rats were assigned into 3 groups, as follows; Group 1: Control group, Group 2: Only cisplatin administered group for 14 days (Cisplatin group), and Group 3: Taxifolin + cisplatin administered group for 14 days (CIS + TAX group). Serum malondialdehyde (MDA), total Glutathione (tGSH), Nuclear Factor-Kappa B (NF-ƘB), Total Oxidative Status (TOS) and Total Antioxidant Status (TAS) levels were collected from the left eyes of rats. Rats' right eyes were enucleated for histopathological evaluations of optic nerves. NF-ƘB, MDA and TOS levels were statistically significantly higher (p 
ISSN:1556-9527
1556-9535
DOI:10.1080/15569527.2020.1844726