Synthesis and in vitro antiproliferative activities of lupanol derivatives towards human esophageal squamous carcinoma cells

A series of lupanol derivatives were synthesized and evaluated in vitro for their inhibitory activities against three human esophageal squamous carcinoma cells lines, Eca-109, TE-1 and EC-9706. Among lupanol derivatives, seven were new compounds, and lupanol cinnamate analogues 5 and 6, hydrazone an...

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Bibliographic Details
Published in:Natural product research 2022-02, Vol.36 (4), p.896-900
Main Authors: Li, Weijie, Xiao, Yeyu
Format: Article
Language:English
Subjects:
anticancer activity
Antineoplastic Agents - pharmacology
Carcinoma, Squamous Cell - drug therapy
Cell Line, Tumor
Cell Proliferation
Drug Screening Assays, Antitumor
Humans
Hydrazones
Hydrazones - pharmacology
Lupanol
lupanol derivative
Structure-Activity Relationship
synthesis
Tumors
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Summary:A series of lupanol derivatives were synthesized and evaluated in vitro for their inhibitory activities against three human esophageal squamous carcinoma cells lines, Eca-109, TE-1 and EC-9706. Among lupanol derivatives, seven were new compounds, and lupanol cinnamate analogues 5 and 6, hydrazone analogues 9 and 10 presented high activities towards all the tested tumour cells, even higher activities than those of doxorubicine.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2020.1844687